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un material inert. 4. REFERINȚE BIBLIOGRAFICE: (1) Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria. 3rd revised edition. UN Publication No: ST/SG/AC.10/1 I/Rev. 3, 1999, page 342. Test O.2: Test for oxidizing liquids. Figură 1 Vas de presiune (A) Corpul vasului de presiune (B) Dop de fixare disc de rupere (C) Dop de aprindere D) Șaiba din plumb moale (E) Disc de rupere (F) Braț lateral G) Cap traductor de presiune
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classification of substances and preparations on the basis of their acute toxicity. Human Toxicol., 3, 85-92. (2) Van den Heuvel, M.J., Dayan, A.D. and Shillaker, R.O. (1987). Evaluation of the BTS approach to the testing of substances and preparations for their acute toxicity. Human Toxicol., 6, 279-291. (3) Van den Heuvel, M.J., Clark, D.G., Fielder, R.J., Koundakjian, P.P., Oliver, G.J.A., Pelling, D., Tomlinson, N.J. and Walker, A.P. (1990). The internațional validation of a fixed-dose procedure aș an alternative to
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7) OECD (2001). Guidance Document on Acute Oral Toxicity Testing. Environmental Health and Safety Monograph Series on Testing and Assessment N. 24. Paris (8) OECD (2000). Guidance Document on the Recognition, Assessment and Use of Clinical Signs aș Humane Endpoints for Experimental Animals Used în Safety Evaluation. Environmental Health and Safety Monograph Series on Testing and Assesment N. 19. (9) OECD (1998). Harmonised Integrated Hazard Classification for Human Health and Environmental Effects of Chemical Substances aș endorsed by the 28th Joint
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Guidance Document on the Recognition, Assessment and Use of Clinical Signs aș Humane Endpoints for Experimental Animals Used în Safety Evaluation. Environmental Health and Safety Monograph Series on Testing and Assesment N. 19. (9) OECD (1998). Harmonised Integrated Hazard Classification for Human Health and Environmental Effects of Chemical Substances aș endorsed by the 28th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals în November 1998, Part 2, p. 11 [http://webnet 1.oecd.org/oecd/pages/home
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8) OECD (2001) Guidance Document on Acute Oral Toxicity Testing. Environmental Health and Safety Monograph Series on Testing and Assessment N. 24. Paris. (9) OECD (2000) Guidance Document on the Recognition, Assessment and Use of Clinical Signs aș Humane Endpoints for Experimental Animals Used în Safety Evaluation. Environmental Health and Safety Monograph Series on Testing and Assessment N 19. (10) OECD (1998) Harmonised Integrated Hasard Classification System For Human Health And Environmental Effects Of Chemical Substances aș endorsed by the 28th
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Document on the Recognition, Assessment and Use of Clinical Signs aș Humane Endpoints for Experimental Animals Used în Safety Evaluation. Environmental Health and Safety Monograph Series on Testing and Assessment N 19. (10) OECD (1998) Harmonised Integrated Hasard Classification System For Human Health And Environmental Effects Of Chemical Substances aș endorsed by the 28th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals în November 1998, Part 2, p. 11 [http://webnet 1.oecd.org/oecd/pages/home
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4. REFERINȚE BIBLIOGRAFICE: (1) Barratt, M.D., Castell, J.V., Chamberlain, M., Combes, R.D., Dearden, J.C., Fentem, J.H., Gerner, I., Giuliani, A., Gray, T.J.B., Livingston, D.J., Provan, W.M., Rutten, F.A.J.J.L., Verhaar, H.J.M., Zbinden, P. (1995) The Integrated Use of Alternative Approaches for Predicting Toxic Hazard. ECVAM Workshop Report 8. ATLA 23, 410 - 429. (2) Young, J.R., How, M.J., Walker, A.P., Worth W.M.H. (1988) Classification aș Corrosive or Irritant to Skin of Preparations Containing Acidic or Alkaline Substance Without Testing on Animals
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Containing Acidic or Alkaline Substance Without Testing on Animals. Toxicol. In Vitro, 2, 19 -26. (3) Worth, A.P., Fentem, J.H., Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Esdaile, D.J., Liebsch, M. (1998) Evaluation of the proposed OECD Testing Strategy for skin corrosion. ATLA 26, 709-720. (4) ECETOC (1990) Monograph No. 15, "Skin Irritation", European Chemical Industry, Ecology and Toxicology Centre, Brussels. (5) Fentem, J.H., Archer, G.E.B., Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Edsail, D.J., Holzhutter, H.G. and Liebsch
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Skin Irritation", European Chemical Industry, Ecology and Toxicology Centre, Brussels. (5) Fentem, J.H., Archer, G.E.B., Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Edsail, D.J., Holzhutter, H.G. and Liebsch, M. (1998) The ECVAM internațional validation study on in vitro tests for skin corrosivity. 2. Results and evaluation by the Management Team. Toxicology in Vitro 12, pp. 483 - 524. (5a) Metodă de testare B.40 Coroziune dermica. (6) OECD (1996) OECD Test Guidelines Programme: Final Report of the OECD Workshop on Harmonization
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evaluation by the Management Team. Toxicology in Vitro 12, pp. 483 - 524. (5a) Metodă de testare B.40 Coroziune dermica. (6) OECD (1996) OECD Test Guidelines Programme: Final Report of the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods. Held în Solna, Sweden, 22 - 24 January 1996 (http://www.oecd1 .org/ehs/test/background.htm). (7) OECD (1998) Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances, aș endorsed by
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of the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods. Held în Solna, Sweden, 22 - 24 January 1996 (http://www.oecd1 .org/ehs/test/background.htm). (7) OECD (1998) Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances, aș endorsed by the 28th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, November 1998 (http://www.oecd1.org/ehs/Class/HCL6.htm). (8) OECD (2000). Guidance Document
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28th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, November 1998 (http://www.oecd1.org/ehs/Class/HCL6.htm). (8) OECD (2000). Guidance Document on the Recognition, Assessment and Use of Clinical Signs aș Humane Endpoints for Experimental Animals Used în Safety Evaluation. OECD Environmental Health and Safety Publications. Series on Testing and Assessment No. 19 (http://www.oecd1.org/ehs/test/monos.htm). (9) EPA (1990). Atlas of Dermal Lesions, (20T-2004). United States Environmental Protection Agency
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în prezența anexă a fost dezvoltată în cadrul unui atelier de lucru OCDE (1) și a fost ulterior susținută și extinsă în cadrul Sistemului armonizat integrat de clasificare a riscurilor substanțelor chimice pentru sănătatea oamenilor și mediu (Harmonised Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances), adoptată la a 28-a reuniune comună a Comitetului pentru substanțe chimice și a Grupului de lucru pentru substanțe chimice, în noiembrie 1998 (2). Deși această strategie de testare secvențiala nu face
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se observă un efect iritant, testul de confirmare poate fi efectuat secvențial sau prin expunerea altor două animale simultan. REFERINȚE BIBLIOGRAFICE: (1) OECD (1996). Test Guidelines Programme: Final Report on the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods. Held on Solna, Sweden, 22 - 24 January 1996 (http://www1.oecd.org/ehs/test/background.htm). (2) OECD (1998). Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances, aș endorsed by
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on the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods. Held on Solna, Sweden, 22 - 24 January 1996 (http://www1.oecd.org/ehs/test/background.htm). (2) OECD (1998). Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances, aș endorsed by the 28th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, November 1998 (http://www1.oecd.org/ehs/Class/HCL6.htm). (3) Worth, A.P., Fentem J.H.
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Working Party on Chemicals, November 1998 (http://www1.oecd.org/ehs/Class/HCL6.htm). (3) Worth, A.P., Fentem J.H., Balls M., Botham P.A., Curren R.D., Earl L.K., Esdaile D.J., Liebsch M. (1998). An Evaluation of the Proposed OECD Testing Strategy for Skin Corrosion. ATLA 26, 709-720. (4) Young, J.R., How, M.J., Walker, A.P., Worth, W.M.H. (1988). Classification aș Corrosive or Irritant to Skin of Preparations Containing Acidic or Alkaline Substances, Without Testing on Animals. Toxic In Vitro, 2 (1) pp.
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Classification aș Corrosive or Irritant to Skin of Preparations Containing Acidic or Alkaline Substances, Without Testing on Animals. Toxic In Vitro, 2 (1) pp. 19-26. (5) Patil, S.M., Patrick, E., Maibach, H.I. (1996) Animal, Human, and In Vitro Test Methods for Predicting Skin Irritation, în: Francis N. Marzulli and Howard I. Maibach (editors): Dermatotoxicology. Fifth Edition ISBN 1-56032-356-6, Chapter 31, 411-436. (6) Metodă de testare B.40. (7) Fentem, J.H., Archer, G.E.B., Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Esdaile
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1-56032-356-6, Chapter 31, 411-436. (6) Metodă de testare B.40. (7) Fentem, J.H., Archer, G.E.B., Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Esdaile, D.J., Holzhutter, H.G. and Liebsch, M. (1998) The ECVAM internațional validation study on in vitro tests for skin corrosivity. 2. Results and evaluation by the Management Team. Toxicology in Vitro 12, pp. 483 - 524. FIGURĂ STRATEGIE DE TESTARE ȘI EVALUARE A IRITAȚIEI/COROZIUNII DERMICE Activitate Observații Concluzie 1 Date existente privind efectele asupra oamenilor/animalelor care indică
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4. REFERINȚE BIBLIOGRAFICE: (1) Barratt, M.D., Castell, J.V., Chamberlain, M., Combes, R.D., Dearden, J.C., Fentem, J.H., Gerner, I., Giuliani, A., Gray, T.J.B., Livingston, D.J., Provan, W.M., Rutten, F.A.J.J.L., Verhaar, H.J.M., Zbinden, P. (1995) The Integrated Use of Alternative Approaches for Predicting Toxic Hazard. ECVAM Workshop Report 8. ATLA 23, 410 - 429. (2) de Silva, O., Cottin, M., Dami, N., Roguet, R., Catroux, P., Toufic, A., Sicard, C., Dossou, K.G., Gerner, I., Schlede, E., Spielmann, H., Gupta, K.C., Hill, R.N. (1997
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Dossou, K.G., Gerner, I., Schlede, E., Spielmann, H., Gupta, K.C., Hill, R.N. (1997) Evaluation of Eye Irritation Potențial: Statistical Analysis and Tier Testing Strategies. Food Chem. Toxicol 35, 159 - 164. (3) Worth A.P. and Fentem J.H. (1999) A general approach for evaluating stepwise testing strategies, ATLA 27, 161-177 (4) Young, J.R., How, M.J., Walker, A.P., Worth W.M.H. (1988) Classification aș Corrosive or Irritant to Skin of Preparations Containing Acidic or Alkaline Substance Without Testing on Animals. Toxicol. In Vitro, 2
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Single pH. J. Toxicol. Cut. Ocular Toxicol. 12, 227 - 231. (6) Fentem, J.H., Archer, G.E.B., Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Edsaile, D.J., Holzhutter, H.G. and Liebsch, M. (1998) The ECVAM internațional validation study on in vitro tests for skin corrosivity. 2. Results and evaluation by the Management Team. Toxicology in Vitro 12, pp. 483-524. (6a) Metodă de testare B.40. Coroziune dermica. (7) Metodă de testare B.4. Toxicitate acută: iritație/coroziune dermica. (8) OECD (1996) OECD Test
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483-524. (6a) Metodă de testare B.40. Coroziune dermica. (7) Metodă de testare B.4. Toxicitate acută: iritație/coroziune dermica. (8) OECD (1996) OECD Test Guidelines Programme: Final Report of the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods. Held în Solna, Sweden, 22 - 24 January 1996 (http://www.oecd.org/ehs/test/background.htm). (9) OECD (1998) Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances, aș endorsed by
32004L0073-ro () [Corola-website/Law/292696_a_294025]
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of the OECD Workshop on Harmonization of Validation and Acceptance Criteria for Alternative Toxicological Test Methods. Held în Solna, Sweden, 22 - 24 January 1996 (http://www.oecd.org/ehs/test/background.htm). (9) OECD (1998) Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances, aș endorsed by the 28th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, November 1998 (http://www.oecd.org/ehs/Class/HCL6.htm). (10) OECD (2000) Guidance Document
32004L0073-ro () [Corola-website/Law/292696_a_294025]
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28th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, November 1998 (http://www.oecd.org/ehs/Class/HCL6.htm). (10) OECD (2000) Guidance Document on the Recognition, Assessment and Use of Clinical Signs aș Humane Endpoints for Experimental Animals Used în Safety Evaluation. OECD Environmental Health and Safety Publications. Series on Testing and Assessment No. 19 (http://www.oecd.org/ehs/test/monos.htm). TABELUL 1: PUNCTAREA LEZIUNILOR OCULARE Cornee Opacitate: nivel de densitate (examinarea se face
32004L0073-ro () [Corola-website/Law/292696_a_294025]
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în prezența anexă a fost dezvoltată în cadrul unui atelier de lucru OCDE (1). Ulterior, ea a fost susținută și extinsă în cadrul Sistemului armonizat integrat de clasificare a riscurilor substanțelor chimice pentru sănătatea oamenilor și mediu (Harmonised Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances), adoptat la a 28-a reuniune comună a Comitetului pentru substanțe chimice și a Grupului de lucru pentru substanțe chimice, în noiembrie 1998 (2). Deși această strategie de testare nu face parte
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