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grip Strength of Rats and Mice. Neurobehav. Toxivol., 1, pp. 233-236. (6) Crofton K. M., Howard J. L., Moser V. C., Gill M. W., Reiter L. W., Tilson H. A., MacPhail R. C. (1991). Interlaboratory Comparison of Motor Activity Experiments: Implication for Neurotoxicological Assessments. Neurotoxicol. Teratol., 13, pp. 599-609. (7) Weingand K., Brown G., Hall R. et al. (1996). "Harmonisation of Animal Clinic Pathology Testing în Toxicity and Safety Studies", Fundam. & Appl. Toxicol., 29, pp. 198-201. ANEXĂ 5E B.27 TESTUL DE

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caz, - incidența oricăror reacții neobișnuite a peștilor și orice efecte vizibile provocate de substanță testată. 3. BIBLIOGRAFIE (1) Solbe J. F. de LG (1987). Environmental Effects of Chemicals (CFM 9350 SLD). Report on a UK Ring Test of a Method for Studying the Effects of Chemicals on the Growth Rate of Fish. WRc Report No PRD 1388-M/2. (2) Meyer, A., Bierman, C. H. and Orți, G. (1993). The phylogenetic position of the zebrafish (Danio rerio), a model system în

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zebrafish (Danio rerio), a model system în developmental biology: an invitation to the comparative method. Proc. R. Șoc. Lond. B. 252, pp. 231-236. (3) Ashley S., Mallett M. J. and Grandy N. J. (1990). EEC Ring Test of a Method for Determining the Effects of Chemicals on the Growth Rate of Fish. Final Report to the Commission of the European Communities. WRc Report No EEC 2600-M. (4) Crossland N. O. (1985). A method to evaluate effects of toxic chemicals on

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D. E., Leonard, E. N. and Johnson, R. D. (1995). Acute and long-term effects of nine chemicals on the Japanese medaka (Oryzias latipes). Arch. Environ. Conta. Toxicol. 28, pp. 287-297. (8) Benoit, D. A., Holcombe, G. W. and Spehar, R. L. (1991). Guidelines for conducting early life toxicity tests with Japanese medaka (Oryzias latipes). Ecological Research Seriese PA-600/3-91-063. USE nvironmental Protection Agency, Duluth, Minnesota. (9) Stephan C. E. and Rogers J. W. (1985). Advantages of using regression analysis to calculate results of chronic toxicity

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fish (rainbow trout, coho salmon, or atlantic salmon). Conservation and Protection, Ontario, Report EPS 1/RM/28, 81 pp. (11) Cox D. R. (1958). Planning of experiments. Wiley Edt. (12) Pack S. (1991). Statistical issues concerning the design of tests for determining the effects of chemicals on the growth rate of fish. Room Document 4, OECD Ad Hoc Meeting of Experts on Aquatic Toxicology, WRc Medmenham, UK, 10-12 December 1991. (13) Dunnett C. W. (1955). A Multiple Comparisons Procedure for Comparing

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
tests for determining the effects of chemicals on the growth rate of fish. Room Document 4, OECD Ad Hoc Meeting of Experts on Aquatic Toxicology, WRc Medmenham, UK, 10-12 December 1991. (13) Dunnett C. W. (1955). A Multiple Comparisons Procedure for Comparing Several Treatments with a Control, J. Amer. Statist. Assoc., 50, pp. 1096-1121. (14) Dunnett C. W. (1964). New tables for multiple comparisons with a control. Biometrics, 20, pp. 482-491. (15) Williams D. A. (1971). A test for differences between treatment

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
Experts on Aquatic Toxicology, WRc Medmenham, UK, 10-12 December 1991. (13) Dunnett C. W. (1955). A Multiple Comparisons Procedure for Comparing Several Treatments with a Control, J. Amer. Statist. Assoc., 50, pp. 1096-1121. (14) Dunnett C. W. (1964). New tables for multiple comparisons with a control. Biometrics, 20, pp. 482-491. (15) Williams D. A. (1971). A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics 27, pp. 103-117. (16) Johnston, W. L., Atkinson

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
Multiple Comparisons Procedure for Comparing Several Treatments with a Control, J. Amer. Statist. Assoc., 50, pp. 1096-1121. (14) Dunnett C. W. (1964). New tables for multiple comparisons with a control. Biometrics, 20, pp. 482-491. (15) Williams D. A. (1971). A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics 27, pp. 103-117. (16) Johnston, W. L., Atkinson, J. L., Glanville N. Ț. (1994). A technique using sequential feedings of different coloured food to

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33-41. (22) Post, G. (1987). Nutrition and Nutrițional Diseases of Fish. Chapter IX în Testbook of Fish Health. T.F.H. Publications, Inc. Neptune City, New Jersey, UȘA. 288 pp. (22) Bruce, R. D. and Versteeg D. J. (1992). A statistical procedure for modelling continuous toxicity dată. Environ. Toxicol. Chem. 11, pp. 1485-1494. (22) DeGraeve, G. M., Cooney, J. M., Pollock, Ț. L., Reichenbach, J. H., Dean, Marcus, M. D. and McIntyre, D. O. (1989). Precision of EPA seven-day fathead minnow larval survival

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O. (1989). Precision of EPA seven-day fathead minnow larval survival and growth test; intra and interlaboratory study. Report EA-6189 (American Petroleum Institute Publication, No 4468). Electric Power Research Institute, Palo Alto, CA. (22) Norbert-King Ț. J. (1988). An interpolation estimate for chronic toxicity: the Icp approach. USE nvironmental Protection Agency. Environmental Research Lab., Duluth, Minnesota. Tech. Rep. No 05-88 of Național Effluent Toxicity Assesment Center. Sept. 1988. 12 pp. (22) Williams D. A. (1972). The comparison of several dose levels with a

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Kristensen P. (1990). Evaluation of the Sensitivity of Short Term Fish Early Life Stage Tests în Relation to other FELS Test Methods. Final report to the Commission of the European Communities, 60 pp. June 1990. (2) ASTM (1988). Standard Guide for Conducting Early Life-Stage Toxicity Tests with Fishes. American Society for Testing and Materials. E 1241-88. 26 pp. (3) Brauhn J. L. and Schoettger R. A. (1975). Acquisition and Culture of Research Fish: Rainbow trout, Fathead minnows, Channel Catfish and Bluegills. p.

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Fish Early Life Stage Tests în Relation to other FELS Test Methods. Final report to the Commission of the European Communities, 60 pp. June 1990. (2) ASTM (1988). Standard Guide for Conducting Early Life-Stage Toxicity Tests with Fishes. American Society for Testing and Materials. E 1241-88. 26 pp. (3) Brauhn J. L. and Schoettger R. A. (1975). Acquisition and Culture of Research Fish: Rainbow trout, Fathead minnows, Channel Catfish and Bluegills. p. 54, Ecological Research Series, EPA-660/3-75-011, Duluth, Minnesota. (4) Brungs

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
J. L. and Schoettger R. A. (1975). Acquisition and Culture of Research Fish: Rainbow trout, Fathead minnows, Channel Catfish and Bluegills. p. 54, Ecological Research Series, EPA-660/3-75-011, Duluth, Minnesota. (4) Brungs W. A. and Jones B. R. (1977). Temperature Criteria for Freshwater Fish: Protocol and Procedures. p. 128, Ecological Research Series EPA-600/3-77-061, Duluth, Minnesota. (5) Laale H. W. (1977). The Biology and Use of the Zebrafish (Brachydanio rerio) în Fisheries Research. A Literature Review. J. Biol. 10, pp. 121-173. (6

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p. 128, Ecological Research Series EPA-600/3-77-061, Duluth, Minnesota. (5) Laale H. W. (1977). The Biology and Use of the Zebrafish (Brachydanio rerio) în Fisheries Research. A Literature Review. J. Biol. 10, pp. 121-173. (6) Legault R. (1958). A Technique for Controlling the Time of Daily Spawning and Collecting Eggs of the Zebrafish, Brachydanio rerio (Hamilton-Buchanan) Copeia, 4, pp. 328-330. (7) Dave G., Damgaard B., Grande M., Martelin J. E., Rosander B. and Viktor Ț. (1987). Ring Test of an Embryo-larval

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
Test of an Embryo-larval Toxicity Test with Zebrafish (Brachydanio rerio) Using Chromium and Zinc aș Toxicants. Environmental Toxicology and Chemistry, 6, pp. 61-71. (8) Birge J. W., Black J. A. and Westerman A. G. (1985). Short-term Fish and Amphibian Embryo-larval Tests for Determining the Effects of Toxicant Stress on Early Life Stages and Estimating Chronic Values for Single Compounds and Complex Effluents. Environmental Toxicology and Chemistry 4, pp. 807-821. (9) Van Leeuwen C. J., Espeldoorn A. and Mol F. (1986). Aquatic Toxicological Aspects

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
Toxicants. Environmental Toxicology and Chemistry, 6, pp. 61-71. (8) Birge J. W., Black J. A. and Westerman A. G. (1985). Short-term Fish and Amphibian Embryo-larval Tests for Determining the Effects of Toxicant Stress on Early Life Stages and Estimating Chronic Values for Single Compounds and Complex Effluents. Environmental Toxicology and Chemistry 4, pp. 807-821. (9) Van Leeuwen C. J., Espeldoorn A. and Mol F. (1986). Aquatic Toxicological Aspects of Dithiocarbamates and Related Compounds. III. Embryolarval Studies with Rainbow Trout (Salmo gairdneri). J. Aquatic

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32(4): 1-4. Carolina Biological Supply Company. (11) Kirchen R. V. and W. R. West (1976). The Japanese Medaka. Its care and Development. Carolina Biological Supply Company, North Carolina. 36 pp. (12) Dunnett C. W. (1955). A Multiple Comparisons Procedure for Comparing Several Treatments with Control. J. Amer. Statist. Assoc., 50, pp. 1096-1121. (13) Dunnett C. W. (1964). New Tables for Multiple Comparisons with a Control. Biometrics, 20, pp. 482-491. (14) Mc Clave J. Ț., Sullivan J. H. and Pearson J.G.

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
care and Development. Carolina Biological Supply Company, North Carolina. 36 pp. (12) Dunnett C. W. (1955). A Multiple Comparisons Procedure for Comparing Several Treatments with Control. J. Amer. Statist. Assoc., 50, pp. 1096-1121. (13) Dunnett C. W. (1964). New Tables for Multiple Comparisons with a Control. Biometrics, 20, pp. 482-491. (14) Mc Clave J. Ț., Sullivan J. H. and Pearson J.G. (1980). Statistical Analysis of Fish Chronic Toxicity Test Dată. Proceedings of 4th Aquatic Toxicology Symposium, ASTM, Philadelphia. (15) Van Leeuwen

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J. Ț., Sullivan J. H. and Pearson J.G. (1980). Statistical Analysis of Fish Chronic Toxicity Test Dată. Proceedings of 4th Aquatic Toxicology Symposium, ASTM, Philadelphia. (15) Van Leeuwen C. J., Adema D. M. M. and Hermes J. (1990). Quantitative Structure-Activity Relationships for Fish Early Life Stage Toxicity. Aquatic Toxicology, 16, pp. 321-334. (16) Environment Canada. (1992). Toxicity Tests Using Early Life Stages of Salmonid Fish (Rainbow Trout, Coho Salmon or Atlantic Salmon). Biological Test Method Series. Report EPS 1/RM/28, December

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252: pp. 231-236. (19) Ghillebaert F., Chaillou C., Deschamps F. and Roubaud P. (1995). Toxic Effects, at Three pH Levels, of Two Reference Molecules on Common Carp Embryo. Ecotoxicology and Environmental Safety 32, pp. 19-28. (20) UȘ EPA, (1991). Guidelines for Culturing the Japanese Medaka, Oryzias latipes. EPA report EPA/600/3-91/064, Dec. 1991, EPA, Duluth. (21) UȘ EPA, (1991). Guidelines for Conducting Early Life Stage Toxicity Tests with Japanese Medaka, (Oryzias latipes). EPA report EPA/600/3-91/063, Dec

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
Reference Molecules on Common Carp Embryo. Ecotoxicology and Environmental Safety 32, pp. 19-28. (20) UȘ EPA, (1991). Guidelines for Culturing the Japanese Medaka, Oryzias latipes. EPA report EPA/600/3-91/064, Dec. 1991, EPA, Duluth. (21) UȘ EPA, (1991). Guidelines for Conducting Early Life Stage Toxicity Tests with Japanese Medaka, (Oryzias latipes). EPA report EPA/600/3-91/063, Dec. 1991, EPA, Duluth. (22) De Graeve G. M., Cooney J. D., McIntyre D. O., Poccocic Ț. L., Reichenbach N. G., Dean J.

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
în the performance of the seven-day Fathead minnow (Pimephales promelas) larval survival and growth test: an intra- and interlaboratory study. Environ. Tox. Chem. 10, pp. 1189-1203. (23) Calow P. (1993). Handbook of Ecotoxicology, Blackwells, Oxford. Vol. 1, Chapter 10: Methods for spawning, culturing and conducting toxicity tests with Early Life stages of Estuarine and Marine fish. (24) Balon E. K. (1985). Early life history of fishes: New developmental, ecological and evolutionary perspectives, Junk Publ., Dordrecht, 280 pp. (25) Blaxter J. H.

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University Press, Great Britain, pp. 1-333. (5) Stephan C. E. (1982). Increasing the Usefulness of Acute Toxicity Tests. Aquatic Toxicology and Hazard Assessment: Fifth Conference, ASTM STP 766, J. G. Pearson, R. B. Foster and W. E. Bishop, Eds., American Society for Testing and Materials, pp. 69-81. (6) Dunnett C. W. (1955). A Multiple Comparisons Procedure for Comparing Several Treatments with a Control. J. Amer. Statist. Assoc., 50, pp. 1096-1121. (7) Dunnett C. W. (1964). New Tables for Multiple Comparisons with a

jrc5127as2001 by Guvernul României (2001) [Corola-website/Law/90295_a_91082]
Toxicity Tests. Aquatic Toxicology and Hazard Assessment: Fifth Conference, ASTM STP 766, J. G. Pearson, R. B. Foster and W. E. Bishop, Eds., American Society for Testing and Materials, pp. 69-81. (6) Dunnett C. W. (1955). A Multiple Comparisons Procedure for Comparing Several Treatments with a Control. J. Amer. Statist. Assoc., 50, pp. 1096-1121. (7) Dunnett C. W. (1964). New Tables for Multiple Comparisons with a Control. Biometrics, 20, pp. 482-491. (8) Williams D. A. (1971). A Test for Differences Between Treatment

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