5,103 matches
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glicerol, izobutenol, Acizi și derivați ai acestora esterul metilic al acidului 2,8dimetilundecanoic acid sorbic MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 31 esterul fenilmetilic al acidului 14 metilpentadecanoic esterul butil-2metilpropilic al acidului ftalic esterul etilic al acidului palmitic metil esterul acidului alnustic Cetone, fenoli și compuși heteroaromatici acetofenonă și derivați, cumarină, p-acetofenol și derivați, esculetol, eugenol, scopoletol, pterostilben, pinosilvină, xanthorrhoeol, trigliceride fenolice. Alcooli terpenici, sesquiterpenici și derivați geraniol, dihidroeudesmol, nerolidol, beta bisabolol, guianol, alfa-acetoxibetulenol, farnesol, Terpenoide și alți compuși cimen
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Burdok, 199896; Marcucci, 199597). Corelația dintre flavonoidele totale și neutralizarea radicalilor liberi îi fac atât de importanți pentru toate aceste activități (Moreno et al., 200098) iar activitatea antitumorală a extractului de propolis depinde doar de activitatea CAPE (caffeic acid phenetyl ester) (Chen et al., 199699; Grumberg et al., 1988100) și 90 Aga, H., T. Shibuya, T. Sugimoto, M. Kurimoto, and S. Nakajima, Isolation and Identification of Antimicrobial Compounds in Brazilian Propolis, Biosci. Biotechnol. Biochem., 58, 945, 1994. 91 Kujumgiev, A., I.
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Sampietro, and M.A. Vattuone, Comparison of the Free Radical-Scavenging Activity of Propolis from Several Regions of Argentina, J Ethnopharmacol., 71, 109, 2000. 99 Chen, J.H., Shao, M.T. Huang, C.K. Chin, and C.T.Ho, Inhibitory Effect of Caffeic Acid Phenethyl Ester on Human Leukemia HL-60 Cells, Cancer Lett., 108, 221, 1996. MICROGRAFII ASUPRA PRODUSELOR APICOLE 38 acidul 3,5 diprenil-4-hidroxicinamic (DHCA) (Kimoto et al., 2001101; Matsuno et al., 1997102; Shimizu et al. 2004103). CAPE CAPE (caffeic acid phenethyl ester), este un
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Acid Phenethyl Ester on Human Leukemia HL-60 Cells, Cancer Lett., 108, 221, 1996. MICROGRAFII ASUPRA PRODUSELOR APICOLE 38 acidul 3,5 diprenil-4-hidroxicinamic (DHCA) (Kimoto et al., 2001101; Matsuno et al., 1997102; Shimizu et al. 2004103). CAPE CAPE (caffeic acid phenethyl ester), este un compus major în propolis care ar putea fi responsabil de protecția asupra creșterilor ureei în sânge și afectării tubilor renali (Ozen et al., 2004104). CAPE poate lega radicalul CCl3· și/sau radicalul CCl3O2, donând un hidrogen radicalului, rupând
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al., 1991106) și administrarea pe termen lung nu produce injurii (Mani et al., 100 Grumberg, D., R. Banerjee, K. Eisinger, E.M. Oltz, L. Efros, M. Caldwell, V. Estevez, and K. Nakanishi, Preferential Cytotoxicity on Tumor Cells by Caffeic Acid Phenethyl Ester Isolated from Propolis, Experientia, 44, 230, 1988. 101 Kimoto, T., M. Aga, K. Hino, S.K. Miyata, Y. Yamamoto, M.J. Micallef, T. Hanaya, S. Arai, M. Ikeda, and M. Kurimoto, Apoptosis of Human Leukemia Cells Induced by Artepillin C, an Active
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and K. Kanazawa, Antioxidative Biovailability of Artepilin C in Brazilian Propolis, Arch. Biochem. Biophys., 424, 181, 2004. 104 Ozen, S., Akyol, O., Iraz, M., Sogut, S., Ozugurlu, F., Ozyurt, H., Odaci, E., Yildirim, Z., 2004. Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats. J. Appl. Toxicol. 24, 27-35. 105 Fang, J.G., Lu, M., Chen, Z.H., Zhu, H.H., Li, Y., Yang, L., Wu, L.M., Liu, Z.L., 2002. Antioxidant effects of resveratrol and
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108 Bhadauria Monika, Satendra Kumar Nirala, Sangeeta Shukla, Multiple treatment of propolis extract ameliorates carbon tetrachloride, Food and Chemical Toxicology, 46, 2008, 2703-2712. 109 Sud’ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, Varfolomeev SD. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 1993;329:21- 4. 110 Son S, Lewis BA. Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure-activity relationship. J Agric Food Chem 2002;50:468-
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MA, Korshunova GA, Sumbatyan NV, Varfolomeev SD. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 1993;329:21- 4. 110 Son S, Lewis BA. Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure-activity relationship. J Agric Food Chem 2002;50:468- 72. 111 Nagaoka T, Banskota AH, Tezuka Y, Saiki I, Kadota S. Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line
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radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure-activity relationship. J Agric Food Chem 2002;50:468- 72. 111 Nagaoka T, Banskota AH, Tezuka Y, Saiki I, Kadota S. Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line. Bioorg Med Chem 2002;10:3351- 9. 112 Russo A, Longo R, Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002;73:21-9
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antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line. Bioorg Med Chem 2002;10:3351- 9. 112 Russo A, Longo R, Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002;73:21-9. 113 Song YS, Park EH, Hur GM, Ryu YS, Lee YS, Lee JY, Kim YM, Jin C. Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett 2002;175
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Longo R, Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002;73:21-9. 113 Song YS, Park EH, Hur GM, Ryu YS, Lee YS, Lee JY, Kim YM, Jin C. Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett 2002;175:53-61. 114 Montpied P, De Bock F, Rondouin G, Niel G, Briant L, Courseau AS, Lerner-Natoli M, Bockaert J. Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress
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C. Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett 2002;175:53-61. 114 Montpied P, De Bock F, Rondouin G, Niel G, Briant L, Courseau AS, Lerner-Natoli M, Bockaert J. Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures. Mol Brain Res 2003;115:111-20. 115 Fadillioglu E, Oztas E, Erdogan H, Yagmurca M, Sogut S, Ucar M, Irmak MK. Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity
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Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures. Mol Brain Res 2003;115:111-20. 115 Fadillioglu E, Oztas E, Erdogan H, Yagmurca M, Sogut S, Ucar M, Irmak MK. Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats. J Appl Toxicol 2004;24:47-52. MICROGRAFII ASUPRA PRODUSELOR APICOLE 40 experimentale efectuate privind efectele protectoare ale CAPE asupra hepatotoxicității induse de CCl4 (Mahran et al., 1996116; Merino et al., 1996117; Sharma et al., 1997118
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hepatotoxicity in rats. Indian J Pharmacol 1997;29: 76-81. 119 Guarini I, Su ZZ, Zucker S, Lan J, Grunberger D, Fisher PB. Growth inhibition and modulation of antigenic phenotype in human melanoma and glioblastoma multiforme cells by caffeic acid phenethyl ester (CAPE). Cell Mol Biol 1992;38:513-27. 120 Orban Z, Mitsiades N, Burkes TR, Tsokos M, Chrousos GP. Caffeic acid phenethyl ester induces leukocyte apoptosis modulates nuclear factor-K B and suppress acute inflammation. Neuroimmunomodulation 2000;7: 99-105. 121 Song YS
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Growth inhibition and modulation of antigenic phenotype in human melanoma and glioblastoma multiforme cells by caffeic acid phenethyl ester (CAPE). Cell Mol Biol 1992;38:513-27. 120 Orban Z, Mitsiades N, Burkes TR, Tsokos M, Chrousos GP. Caffeic acid phenethyl ester induces leukocyte apoptosis modulates nuclear factor-K B and suppress acute inflammation. Neuroimmunomodulation 2000;7: 99-105. 121 Song YS, Park EH, Hur GM, Ryu YS, Lee YS, Lee JY, Kim YM, Jin C. Caffeic acid phenethyl ester inhibits nitric oxide synthase
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GP. Caffeic acid phenethyl ester induces leukocyte apoptosis modulates nuclear factor-K B and suppress acute inflammation. Neuroimmunomodulation 2000;7: 99-105. 121 Song YS, Park EH, Hur GM, Ryu YS, Lee YS, Lee JY, Kim YM, Jin C. Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett 2002;175:53-61. 122 Grunberger, D., Banerjee, R., Eisinger, K., Oltz, E.M., Efros, L., Caldwell, M., Estevez, V., Nakanishi, K., 1988. Preferential cytotoxicity on tumor cells by caffeic acid
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nitric oxide synthase gene expression and enzyme activity. Cancer Lett 2002;175:53-61. 122 Grunberger, D., Banerjee, R., Eisinger, K., Oltz, E.M., Efros, L., Caldwell, M., Estevez, V., Nakanishi, K., 1988. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 44, 230-232. 123 Fruehauf, J.P., Meyskens Jr., F.L., 2007. Reactive oxygen species: a breath of life or death? Clin. Cancer Res. 13, 789-794. 124 Orban, Z., Mitsiades, N., Burke Jr., T.R., Tsokos, M., Chrousos, G.P., 2000
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Experientia 44, 230-232. 123 Fruehauf, J.P., Meyskens Jr., F.L., 2007. Reactive oxygen species: a breath of life or death? Clin. Cancer Res. 13, 789-794. 124 Orban, Z., Mitsiades, N., Burke Jr., T.R., Tsokos, M., Chrousos, G.P., 2000. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation 7, 99-105. 125 Nagaoka, T., Banskota, A.H., Tezuka, Y., Midorikawa, K., Matsushige, K., Kadota, S., 2003. Caffeic acid phenethyl ester (CAPE) analogues: potent nitric oxide inhibitors from
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M., Chrousos, G.P., 2000. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation 7, 99-105. 125 Nagaoka, T., Banskota, A.H., Tezuka, Y., Midorikawa, K., Matsushige, K., Kadota, S., 2003. Caffeic acid phenethyl ester (CAPE) analogues: potent nitric oxide inhibitors from the Netherlands propolis. Biol. Pharm. Bull. 26, 487- 491. MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 41 (Ilhan et al., 2004126) și antiaterosclerotic (Hishikawa et al., 2003127), agent în diverse sisteme. CAPE a
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rapid la necroză hepatică severă și la steatoză (Brautbar și Williams, 2002; Brent și Rumak, 1993131; Manibusan et al., 2007132). Creșterile TGO, TGP și a 126 Ilhan, A., Iraz, M., Gurel, A., Armutcu, F., Kyol, O., 2004. Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice. Neurochem. Res. 29, 2287-2292. 127 Hishikawa, K., Nakaki, T., Fujita, T., 2005. Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25, 442-446
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Fujita, T., 2005. Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25, 442-446. 128 Kus, I., Colakoglu, N., Pekmez, H., Seckin, D., Ogeturk, M., Sarsilmaz, M., 2004. Protective effects of caffeic acid phenethyl ester (CAPE) on carbon tetrachlorideinduced hepatotoxicity in rats. Acta. Histochem. 106, 289- 297. 129 Ogeturk, M., Kus, I., Colakoglu, N., Zararsiz, I., Ilhan, N., Sarsilmaz, M., 2005. Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J. Ethnopharmacol
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M., Sarsilmaz, M., 2004. Protective effects of caffeic acid phenethyl ester (CAPE) on carbon tetrachlorideinduced hepatotoxicity in rats. Acta. Histochem. 106, 289- 297. 129 Ogeturk, M., Kus, I., Colakoglu, N., Zararsiz, I., Ilhan, N., Sarsilmaz, M., 2005. Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J. Ethnopharmacol. 97, 273-280. 130 Iraz, M., Ozerol, E., Gulec, M., Tasdemir, S., Idiz, N., Fadillioglu, E.,Naziroglu, M., Akyol, O., 2006. Protective effect of caffeic acid phenethyl ester (CAPE) administration on
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Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J. Ethnopharmacol. 97, 273-280. 130 Iraz, M., Ozerol, E., Gulec, M., Tasdemir, S., Idiz, N., Fadillioglu, E.,Naziroglu, M., Akyol, O., 2006. Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin induced oxidative damage to liver in rat. Cell Biochem. Funct. 24, 357-361. 131 Brent, J.A., Rumack, B.H., 1993. Role of free radicals in toxic hepatic injury. II. Are free radicals the cause of toxin-induced liver
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Maeda, S., Kim, K., Elsharkawy,A.M., Karin, M., 2007. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124. 135 Choi, K., Han, Y.H., Choi, C., 2007. N-Acetyl cysteine and caffeic acid phenethyl ester sensitize astrocytoma cells to Fas-mediated cell death in a redox-dependent manner. Cancer Lett. 257, 79-86. 136 Yin, X.M., Ding,W.X., 2003. Death receptor activation-induced hepatocyte apoptosis and liver injury. Curr. Mol. Med. 3, 491-508. 137 Malhi, H., Gores
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îmbunătăți starea de sănătate și pentru prevenirea unor afecțiuni inflamatorii, boli cardiace, hepatice, diabet și chiar unele forme de cancer (Mateescu, 2005). Compuși din propolis responsabili de acțiunile sale biologice în ceea ce privește efectele hepatoprotectoare sunt, pentru propolisul european acidul cafeic și esterii acestuia și acidul ferulic 143. Acțiunea antioxidantă a propolisului este dată de flavonoizi, acizi fenolici și esteri ai acestora 144 (Bankova, 2005, citat de Mateescu, 2005). 141 Greceanu A, Enciu V, Observații asupra efectului antibiotic al propolisului, polenului și mierii
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