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Corola-publishinghouse/Science/273_a_935

extracție lichidă la cald a propolisului brazilian solubil în apă, activitatea DPPH de inactivare a radicalilor liberi, precum și citotoxicitatea acestuia asupra celulelor canceroase (Chao et al., 200789). 84 Bruschi, M.L., M.L.C. Cardoso, M.B. Lucchesi, and M.P.D. Gremiăo, Gelatin Microparticles Containing Propolis Obtained by Spray-Drying Technique: Preparation and Characterization, Int. J. Pharm., 264, 45, 2003. 85 Chang, L.H., Y.C. Cheng, and C.M. Chang, Extracting and Purifyng Isoflavones from Defatted Soybean Flakes Using Superheated Water at Elevated Pressures, Food Chem., 84, 279

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
Sasaki, Pressurized Hot Water Extraction of Anthraquinones the Roots of Morinda citrifolia, Biotechnol. Prog., 20, 1872, 2004. 89 Chao R.C., Y.N. Lee, C.M.J. Chang, M.R. Lee, and I.C. Wei, Hot-pressurized fluid extraction of flavonoids and phenolic acids from Brazilian propolis and their cytotoxic assay in vitro, J. of the Chinese Institute of Chemical Engineers, 38, 191-196, 2007. MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 37 Proprietăți farmacodinamice ale propolisului Au fost raportate caracteristici biologice ale propolisului, cum ar fi: antimicrobiene

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
Wei, Hot-pressurized fluid extraction of flavonoids and phenolic acids from Brazilian propolis and their cytotoxic assay in vitro, J. of the Chinese Institute of Chemical Engineers, 38, 191-196, 2007. MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 37 Proprietăți farmacodinamice ale propolisului Au fost raportate caracteristici biologice ale propolisului, cum ar fi: antimicrobiene (Aga et al., 199490 ), antivirale (Kujumgiev et al., 199991), antioxidante (Kumazava et al., 200492), imunomodulatoare (Oršolić et al., 200493), anihilarea radicalilor liberi (Ahn et al., 200494), caracteristici hepatoprotectoare (Banskota

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
phenolic acids from Brazilian propolis and their cytotoxic assay in vitro, J. of the Chinese Institute of Chemical Engineers, 38, 191-196, 2007. MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 37 Proprietăți farmacodinamice ale propolisului Au fost raportate caracteristici biologice ale propolisului, cum ar fi: antimicrobiene (Aga et al., 199490 ), antivirale (Kujumgiev et al., 199991), antioxidante (Kumazava et al., 200492), imunomodulatoare (Oršolić et al., 200493), anihilarea radicalilor liberi (Ahn et al., 200494), caracteristici hepatoprotectoare (Banskota et al., 200095), antiinflamatoare și activitate antitumorală

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
hepatoprotectoare (Banskota et al., 200095), antiinflamatoare și activitate antitumorală (Burdok, 199896; Marcucci, 199597). Corelația dintre flavonoidele totale și neutralizarea radicalilor liberi îi fac atât de importanți pentru toate aceste activități (Moreno et al., 200098) iar activitatea antitumorală a extractului de propolis depinde doar de activitatea CAPE (caffeic acid phenetyl ester) (Chen et al., 199699; Grumberg et al., 1988100) și 90 Aga, H., T. Shibuya, T. Sugimoto, M. Kurimoto, and S. Nakajima, Isolation and Identification of Antimicrobial Compounds in Brazilian Propolis, Biosci

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
de propolis depinde doar de activitatea CAPE (caffeic acid phenetyl ester) (Chen et al., 199699; Grumberg et al., 1988100) și 90 Aga, H., T. Shibuya, T. Sugimoto, M. Kurimoto, and S. Nakajima, Isolation and Identification of Antimicrobial Compounds in Brazilian Propolis, Biosci. Biotechnol. Biochem., 58, 945, 1994. 91 Kujumgiev, A., I. Tsvetkova, Y. Serkedjeva, V. Bankova, R. Christov, and S. Popov, Antibacterial, Antifungical Activity of Propolis of Different Geographic Origin, J. Ethnopharmacol., 64, 235, 1999. 92 Kumazawa, S., T. Hamasaka, and

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
T. Sugimoto, M. Kurimoto, and S. Nakajima, Isolation and Identification of Antimicrobial Compounds in Brazilian Propolis, Biosci. Biotechnol. Biochem., 58, 945, 1994. 91 Kujumgiev, A., I. Tsvetkova, Y. Serkedjeva, V. Bankova, R. Christov, and S. Popov, Antibacterial, Antifungical Activity of Propolis of Different Geographic Origin, J. Ethnopharmacol., 64, 235, 1999. 92 Kumazawa, S., T. Hamasaka, and T. Nakayama, Antioxidant Activity of Propolis of Various Geographic Origins, Food Chem., 84, 329, 2004. 93 Oršolić, N., A.H. Knezević, L. Šver, S. Terzić

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
1994. 91 Kujumgiev, A., I. Tsvetkova, Y. Serkedjeva, V. Bankova, R. Christov, and S. Popov, Antibacterial, Antifungical Activity of Propolis of Different Geographic Origin, J. Ethnopharmacol., 64, 235, 1999. 92 Kumazawa, S., T. Hamasaka, and T. Nakayama, Antioxidant Activity of Propolis of Various Geographic Origins, Food Chem., 84, 329, 2004. 93 Oršolić, N., A.H. Knezević, L. Šver, S. Terzić, and I. Bašić, Immunomodulatory and Antimetastatic Action of Propolis and Related Polyphenolic Compounds, J. Ethnopharmacol., 94, 307, 2004. 94 Ahn, M.R.

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
1999. 92 Kumazawa, S., T. Hamasaka, and T. Nakayama, Antioxidant Activity of Propolis of Various Geographic Origins, Food Chem., 84, 329, 2004. 93 Oršolić, N., A.H. Knezević, L. Šver, S. Terzić, and I. Bašić, Immunomodulatory and Antimetastatic Action of Propolis and Related Polyphenolic Compounds, J. Ethnopharmacol., 94, 307, 2004. 94 Ahn, M.R., S. Kumazawa, T. Hamasaka, K.S. Bang, and T. Nakayama, Antioxidant Activity and Constituents of Propolis Collected in Various Areas of Korea, J. Agric. Food Chem., 52, 7286, 2004

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
Knezević, L. Šver, S. Terzić, and I. Bašić, Immunomodulatory and Antimetastatic Action of Propolis and Related Polyphenolic Compounds, J. Ethnopharmacol., 94, 307, 2004. 94 Ahn, M.R., S. Kumazawa, T. Hamasaka, K.S. Bang, and T. Nakayama, Antioxidant Activity and Constituents of Propolis Collected in Various Areas of Korea, J. Agric. Food Chem., 52, 7286, 2004. 95 Banskota, A.H., Y. Tezuka, I.K. Adnyana, K. Midorikawa, K. Matsushige, D. Message, A.A.G. Huertas, and S. Kadota, Cytotoxic, Hepatoprotective and Free Radical Scavenging Effects

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
in Various Areas of Korea, J. Agric. Food Chem., 52, 7286, 2004. 95 Banskota, A.H., Y. Tezuka, I.K. Adnyana, K. Midorikawa, K. Matsushige, D. Message, A.A.G. Huertas, and S. Kadota, Cytotoxic, Hepatoprotective and Free Radical Scavenging Effects of Propolis from Brazil, Peru, the Netherlands and China, J. Ethnopharmacol., 72, 239, 2000. 96 Burdock, G.A., Review of the Biological Properties and Toxicity of Bee Propolis (Propolis), Food Chem. Toxicol., 36, 347, 1998. 97 Marcucci, M.C., Propolis: Chemical Composition, Biological

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
A.A.G. Huertas, and S. Kadota, Cytotoxic, Hepatoprotective and Free Radical Scavenging Effects of Propolis from Brazil, Peru, the Netherlands and China, J. Ethnopharmacol., 72, 239, 2000. 96 Burdock, G.A., Review of the Biological Properties and Toxicity of Bee Propolis (Propolis), Food Chem. Toxicol., 36, 347, 1998. 97 Marcucci, M.C., Propolis: Chemical Composition, Biological Properties and Therapeutic Activity, Apidologie, 26, 83, 1995. 98 Moreno, M.I.N., M.I. Isla, A.R. Sampietro, and M.A. Vattuone, Comparison of the Free Radical-Scavenging Activity

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
A.G. Huertas, and S. Kadota, Cytotoxic, Hepatoprotective and Free Radical Scavenging Effects of Propolis from Brazil, Peru, the Netherlands and China, J. Ethnopharmacol., 72, 239, 2000. 96 Burdock, G.A., Review of the Biological Properties and Toxicity of Bee Propolis (Propolis), Food Chem. Toxicol., 36, 347, 1998. 97 Marcucci, M.C., Propolis: Chemical Composition, Biological Properties and Therapeutic Activity, Apidologie, 26, 83, 1995. 98 Moreno, M.I.N., M.I. Isla, A.R. Sampietro, and M.A. Vattuone, Comparison of the Free Radical-Scavenging Activity of

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
Scavenging Effects of Propolis from Brazil, Peru, the Netherlands and China, J. Ethnopharmacol., 72, 239, 2000. 96 Burdock, G.A., Review of the Biological Properties and Toxicity of Bee Propolis (Propolis), Food Chem. Toxicol., 36, 347, 1998. 97 Marcucci, M.C., Propolis: Chemical Composition, Biological Properties and Therapeutic Activity, Apidologie, 26, 83, 1995. 98 Moreno, M.I.N., M.I. Isla, A.R. Sampietro, and M.A. Vattuone, Comparison of the Free Radical-Scavenging Activity of Propolis from Several Regions of Argentina, J Ethnopharmacol., 71, 109

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
Food Chem. Toxicol., 36, 347, 1998. 97 Marcucci, M.C., Propolis: Chemical Composition, Biological Properties and Therapeutic Activity, Apidologie, 26, 83, 1995. 98 Moreno, M.I.N., M.I. Isla, A.R. Sampietro, and M.A. Vattuone, Comparison of the Free Radical-Scavenging Activity of Propolis from Several Regions of Argentina, J Ethnopharmacol., 71, 109, 2000. 99 Chen, J.H., Shao, M.T. Huang, C.K. Chin, and C.T.Ho, Inhibitory Effect of Caffeic Acid Phenethyl Ester on Human Leukemia HL-60 Cells, Cancer Lett., 108, 221, 1996. MICROGRAFII ASUPRA

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
HL-60 Cells, Cancer Lett., 108, 221, 1996. MICROGRAFII ASUPRA PRODUSELOR APICOLE 38 acidul 3,5 diprenil-4-hidroxicinamic (DHCA) (Kimoto et al., 2001101; Matsuno et al., 1997102; Shimizu et al. 2004103). CAPE CAPE (caffeic acid phenethyl ester), este un compus major în propolis care ar putea fi responsabil de protecția asupra creșterilor ureei în sânge și afectării tubilor renali (Ozen et al., 2004104). CAPE poate lega radicalul CCl3· și/sau radicalul CCl3O2, donând un hidrogen radicalului, rupând astfel lanțul de reacție a radicalului

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
care poate reacționa a doua oară cu radicalii liberi, formând CAPE orto-quinonă (Fang et al., 2002105). Este deasemenea posibil ca radicalul semiquinonă să se combine cu radicalul triclormetil și/sau radicalul peroxid triclormetil pentru a forma radicalul CAPE aduct corespunzător. Propolisul este relativ netoxic la doze mari (Dobrowolski et al., 1991106) și administrarea pe termen lung nu produce injurii (Mani et al., 100 Grumberg, D., R. Banerjee, K. Eisinger, E.M. Oltz, L. Efros, M. Caldwell, V. Estevez, and K. Nakanishi, Preferential

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
administrarea pe termen lung nu produce injurii (Mani et al., 100 Grumberg, D., R. Banerjee, K. Eisinger, E.M. Oltz, L. Efros, M. Caldwell, V. Estevez, and K. Nakanishi, Preferential Cytotoxicity on Tumor Cells by Caffeic Acid Phenethyl Ester Isolated from Propolis, Experientia, 44, 230, 1988. 101 Kimoto, T., M. Aga, K. Hino, S.K. Miyata, Y. Yamamoto, M.J. Micallef, T. Hanaya, S. Arai, M. Ikeda, and M. Kurimoto, Apoptosis of Human Leukemia Cells Induced by Artepillin C, an Active Ingredient of Brazilian

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
Experientia, 44, 230, 1988. 101 Kimoto, T., M. Aga, K. Hino, S.K. Miyata, Y. Yamamoto, M.J. Micallef, T. Hanaya, S. Arai, M. Ikeda, and M. Kurimoto, Apoptosis of Human Leukemia Cells Induced by Artepillin C, an Active Ingredient of Brazilian Propolis, Anticancer Res., 21, 221, 2001. 102 Matsumo, T., S.K. Jung, Y. Matsumoto, M. Saito, and J. Morikawa, Preferential Cytotoxicity to Tumor Cells of 3,5-Diprenyl-4-Hydroxycinnamic Acid (Artepilin C), Isolated from propolis, Anticancer Res., 17, 3565, 1997. 103 Shimizu, K., H.

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
Induced by Artepillin C, an Active Ingredient of Brazilian Propolis, Anticancer Res., 21, 221, 2001. 102 Matsumo, T., S.K. Jung, Y. Matsumoto, M. Saito, and J. Morikawa, Preferential Cytotoxicity to Tumor Cells of 3,5-Diprenyl-4-Hydroxycinnamic Acid (Artepilin C), Isolated from propolis, Anticancer Res., 17, 3565, 1997. 103 Shimizu, K., H.Ahida, Y. Matsuura, and K. Kanazawa, Antioxidative Biovailability of Artepilin C in Brazilian Propolis, Arch. Biochem. Biophys., 424, 181, 2004. 104 Ozen, S., Akyol, O., Iraz, M., Sogut, S., Ozugurlu, F.

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
Saito, and J. Morikawa, Preferential Cytotoxicity to Tumor Cells of 3,5-Diprenyl-4-Hydroxycinnamic Acid (Artepilin C), Isolated from propolis, Anticancer Res., 17, 3565, 1997. 103 Shimizu, K., H.Ahida, Y. Matsuura, and K. Kanazawa, Antioxidative Biovailability of Artepilin C in Brazilian Propolis, Arch. Biochem. Biophys., 424, 181, 2004. 104 Ozen, S., Akyol, O., Iraz, M., Sogut, S., Ozugurlu, F., Ozyurt, H., Odaci, E., Yildirim, Z., 2004. Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
of Artepilin C in Brazilian Propolis, Arch. Biochem. Biophys., 424, 181, 2004. 104 Ozen, S., Akyol, O., Iraz, M., Sogut, S., Ozugurlu, F., Ozyurt, H., Odaci, E., Yildirim, Z., 2004. Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats. J. Appl. Toxicol. 24, 27-35. 105 Fang, J.G., Lu, M., Chen, Z.H., Zhu, H.H., Li, Y., Yang, L., Wu, L.M., Liu, Z.L., 2002. Antioxidant effects of resveratrol and its analogs against the free-radicalinduced

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
and its analogs against the free-radicalinduced peroxidation of linoleic acid in micelles. Chem. Eur. J. 8, 4191-4198. 106 Dobrowolski, J.W., Vohora, S.B., Sharma, K., Shah, S.A., Naqvi, S.A., Dandiya, P.C., 1991. Antibacterial, antifungal, antiamoebic, anti-inflammatory, and antipyretic studies on propolis bee products. J. Ethnopharmacol. 35, 77-82. MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 39 2006107) care sugerează un spectru larg terapeutic. Extractul de propolis determină o semnificativă recuperare la nivel celular (lucru demonstrat de aducerea în limite normale a unor

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
K., Shah, S.A., Naqvi, S.A., Dandiya, P.C., 1991. Antibacterial, antifungal, antiamoebic, anti-inflammatory, and antipyretic studies on propolis bee products. J. Ethnopharmacol. 35, 77-82. MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 39 2006107) care sugerează un spectru larg terapeutic. Extractul de propolis determină o semnificativă recuperare la nivel celular (lucru demonstrat de aducerea în limite normale a unor parametri biochimici dar și asupra histoarhitecturii patologice) după afectarea indusă de CCl4. Având în vedere potențialul hepatoprotector, propolisul are o importanță clinică deosebită și

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
un spectru larg terapeutic. Extractul de propolis determină o semnificativă recuperare la nivel celular (lucru demonstrat de aducerea în limite normale a unor parametri biochimici dar și asupra histoarhitecturii patologice) după afectarea indusă de CCl4. Având în vedere potențialul hepatoprotector, propolisul are o importanță clinică deosebită și poate fi utilizat pentru a dezvolta un medicament cu activitate hepatoprotectoare sigură (Bhadauria et al., 2008108). CAPE este o componentă activă în extractele de propolis de albine și este recunoscută a avea proprietăți medicale

MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]