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Corola-website/Law/90548_a_91335

GRUPA II 13, 21, 68, 73 3,50 12, 16, 18, 24, 26, 32, 39, 77 4,25 13S, 31, 68S, 83 4,50 27, 29, 78 5,00 GRUPA III Toate categoriile 5,00 1. Țara Grupa Categoria 3. Report (%) Hong Kong GRUPA I 2, 2A, 3, 3A 3,75 4 3,25 5 3,00 6, 6A, 7, 8 2,50 GRUPA II 13, 13S, 21, 73 3,00 18, 68, 68S 3,50 12, 31 4,50 24, 26

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Corola-website/Law/89749_a_90536

ovary cells: Evaluation of 108 chemicals, Environs. Molec. Mutagen 10 (suppl. 10), pp. 1-175. (4) Scott, D., Galloway, S. M., Marshall, R. R., Ishidate, M. Jr., Brusick, D., Ashby, J. and Myhr, B. C. (1991), Genotoxicity under Extreme Culture Conditions. A report from ICPEMC Task Group 9, Mutation Res., 257, pp. 147-204. (5) Morita, T., Nagaki, T., Fukuda, I. and Okumura, K. (1992), Clastogenicity of low pH to Various Cultured Mammalian Cells, Mutation Res., 268, pp. 297-305. (6) Ames, B. N., McCann

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Chromosomal Aberration Tests on 29 Chemicals Combined with S9 Mix In Vitro, Mutation Res., 66, pp. 277-290. (10) Elliot, B. M., Combes, R. D., Elcombe, C. R., Gatehouse, D. G., Gibson, G. G., Mackay, J. M. and Wolf, R. C. (1992), Report of UK environmental Mutagen Society Working Party. Alternatives to Aroclar 1254-induced S9 in In Vitro Genotoxicity Assays, Mutagenesis, 7, pp. 175-177. (11) Matsushima, T., Sawamura, M., Hara, K. and Sugimura, T. (1976), A Safe Substitute for Polychlorinated Biphenyls as an

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J. R. and Philpot, R. M. (eds), In Vitro Metabolic Activation in Mutagenesis Testing, Elsevier, North-Holland, pp. 85-88. (12) Galloway, S. M., Aardema, M. J., Ishidate, M. Jr., Iven, J. L., Kirkland, D. J., Morita, T., Mosesso, P., Sofuni, T. (1994), Report from Working Group on in In Vitro Tests for Chromosomal Aberrations, Mutation Res., 312, pp. 241-261. (13) Richardson, C., Williams, D. A., Allen, J. A., Amphlett, G., Chanter, D. O. and Phillips, B. (1989), Analysis of Data from In Vitro Cytogenetic

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
189, 157-165. (3) Richold, M., Chandly, A., Ashby, J., Gatehouse D. G., Bootman, J. and Henderson, L. (1990), In Vivo Cytogenetic Assays, in: D. J. Kirkland, (ed.), Basic Mutagenicity Tests, UKEMS Recommended Procedures. UKEMS Sub-Committee on Guidelines for Mutagenicity Testing Report. Part I revised, Cambridge University Press, Cambridge, New Cork, Port Chester, Melbourne, Sydney, pp. 115-141. (4) Tice, R. R. Hayashi, M., MacGregor, J. T., Anderson, D., Blakey, D. H., Holden, H. E., Kirch-Volders, M., Oleson Jr., F. B., Paccierotti, F.

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
pp. 115-141. (4) Tice, R. R. Hayashi, M., MacGregor, J. T., Anderson, D., Blakey, D. H., Holden, H. E., Kirch-Volders, M., Oleson Jr., F. B., Paccierotti, F., Preston R. J., Romagna F., Shimada, H., Sutou, S. and Vannier, B. (1994), Report from the Working Group on the In Vivo Mammalian Bone Marrow Chromosomal Aberration Test, Mutation Res., 312, pp. 305-312. (5) Fielder, R. J., Alleen, J. A., Boobis, A. R., Botham, P. A., Doe, J., Esdaile, D. J., Gatehouse, D. G., Hodson-Walker

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Marrow Chromosomal Aberration Test, Mutation Res., 312, pp. 305-312. (5) Fielder, R. J., Alleen, J. A., Boobis, A. R., Botham, P. A., Doe, J., Esdaile, D. J., Gatehouse, D. G., Hodson-Walker, G., Morton, D. B., Kirkland, D. J. and Richold, M. (1992), Report of British Toxicology Society/UK, Environmental Mutagen Society Working Group: Dose setting in In Vivo Mutagenicity Assays, Mutagenesis, 7, pp. 313-319. (6) Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clare, G., Ferguson, R., Richold, M., Papworth, D.

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clare, G., Ferguson, R., Richold, M., Papworth, D. G. and Savage, J. R. K. (1989), Statistical Analysis of In Vivo Cytogenetic Assays, in: UKEMS Sub-Committee on Guidelines for Mutagenicity Testing. Report Part III. Statistical Evaluation of Mutagenicity Test Data, D. J. Kirkland, (ed.) Cambridge University Press, Cambridge, pp. 184-232. (7) Locke-Huhle, C. (1983), Endoreduplication in Chinese hamster cells during alpha-radiation-induced G2 arrest, Mutation Res. 119, pp. 403-413. (8) Huang, Y., Change

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
a Measure of Genotoxicity, Mutation Res. 123, pp. 61-118. (4) Mavournin, K. H., Blakey, D. H., Cimino, M. C., Salamone, M. F. and Heddle, J. A. (1990), The In Vivo Micronucleus Assay in Mammalian Bone Marrow and Peripheral Blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 239, pp. 29-80. (5) MacGregor, J. T., Schlegel, R., Choy, W. N., and Wehr, C. M. (1983), Micronuclei in Circulating Erythrocytes: A Rapid Screen for Chromosomal Damage During Routine Toxicity Testing

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Micronucleus Assay with Mouse Peripheral Blood Reticulocytes Using Acridine Orange-Coated Slides, Mutation Res., 245, pp. 245-249. (9) The Collaborative Study Group for the Micronucleus Test (1992). Micronucleus Test with Mouse Peripheral Blood Erythrocytes by Acridine Orange Supravital Staining: The Summary Report of the 5th Collaborative Study by CSGMT/JEMMS, MMS, Mutation Res., 278, pp. 83-98. (10) The Collaborative Study Group for the Micronucleus Test (CSGMT/JEMMS, MMS: The Mammalian Mutagenesis Study Group of the Environmental Mutagen Society of Japan) (1995). Protocol

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
mouse peripheral blood micronucleus test, Mutagenesis, 10, pp. 313-319. (13) Fielder, R. J., Allen, J. A., Boobis, A. R., Botham, P. A., Doe, J., Esdaile, D. J., Gatehouse, D. G., Hodson-Walker, G., Morton, D. B., Kirkland, D. J. and Rochold, M. (1992), Report of British Toxicology Society/UK Environmental Mutagen Society Working Group: Dose Setting in In Vivo Mutagenicity Assays, Mutagenesis, 7, pp. 313-319. (14) Hayashi, M., Sofuni, T. and Ishidate, M. Jr. (1983), An Application of Acridine Orange Fluorescent Staining to the

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
pp. 97-99. (18) Richold, M., Ashby, J., Bootman, J., Chandley, A., Gatehouse, D. G. and Henderson, L. (1990), In Vivo Cytogenetics Assay, in: D. J. Kirkland (ed.), Basic Mutagenicity tests. UKEMS Recommended Procedures, UKEMS Sub-Committee on Guidelines for Mutagenicity Testing Report, Part I, revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 115-141. (19) Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clare, G., Ferguson, R., Richold, M., Papworth, D. G. and Savage, J. R. K. (1989

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L. D., Brusick, D. J., Auletta, A. E., Von Halle, E. S., Brown, M. M., Simmon, V. F., Dunkel, V., McCann, J., Mortelmans, K., Prival, M., Rao, T. K. and Ray V. (1986), The Salmonella typhimurium/Mammalian Microsomal Assay: A Report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 168, pp. 69-240. (5) Yahagi, T., Degawa, M., Seino, Y.Y., Matsushima, T., Nagao, M., Sugimura, T. and Hashimoto, Y. (1975), Mutagenicity of Carcinogen Azo Dyes and their Derivatives, Cancer

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
paralel, - datele anterioare privind martorii negativi (solvent/vehicul) și pozitivi, cu domeniile, valorile medii și deviațiile standard, - frecvența mutanților. Discutarea rezultatelor. Concluziile. 4. BIBLIOGRAFIA (1) Moore, M.M., DeMarini, D. M., DeSerres, F. J. and Tindall, K. R. (eds.) (1987), Banbury Report 28: Mammalian Cell Mutagenesis, Cold Spring Harbor Laboratory, New York. (2) Chu, E. H. Y. and Malling, H. V. (1968), Mammalian Cell Genetics. II. Chemical Induction of Specific Locus Mutations in Chinese Hamster Cells In Vitro, Proc. Natl. Acad. Sci. USA

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Evaluation of Six Drug Candidates, Mutation Res., 223, pp. 121-128. (6) Aaron, C. S., Bolcsfoldi, G., Glatt, H. R., Moore, M., Nishi, Y., Stankowski, Jr. L. F., Theiss, J. and Thompson, E. (1994), Mammalian Cell Gene Mutation Assays Working Group Report. Report of the International Workshop on Standardisation of Genotoxicity Test Procedures. Mutation Res., 312, pp. 235-239. (7) Scott, D., Galloway, S. M., Marshall, R. R., Ishidate, M., Brusick, D., Ashby, J. and Myhr, B. C. (1991), Genotoxicity Under Extreme Culture Conditions

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
of Six Drug Candidates, Mutation Res., 223, pp. 121-128. (6) Aaron, C. S., Bolcsfoldi, G., Glatt, H. R., Moore, M., Nishi, Y., Stankowski, Jr. L. F., Theiss, J. and Thompson, E. (1994), Mammalian Cell Gene Mutation Assays Working Group Report. Report of the International Workshop on Standardisation of Genotoxicity Test Procedures. Mutation Res., 312, pp. 235-239. (7) Scott, D., Galloway, S. M., Marshall, R. R., Ishidate, M., Brusick, D., Ashby, J. and Myhr, B. C. (1991), Genotoxicity Under Extreme Culture Conditions. A

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
of the International Workshop on Standardisation of Genotoxicity Test Procedures. Mutation Res., 312, pp. 235-239. (7) Scott, D., Galloway, S. M., Marshall, R. R., Ishidate, M., Brusick, D., Ashby, J. and Myhr, B. C. (1991), Genotoxicity Under Extreme Culture Conditions. A report from ICPEMC Task Group 9, Mutation Res., 257, pp. 147-204. (8) Clive, D., McCuen, R., Spector, J. F. S., Piper, C. and Mavournin, K. H. (1983), Specific Gene Mutations in L5178Y Cells in Culture. A Report of the U. S. Environmental

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Extreme Culture Conditions. A report from ICPEMC Task Group 9, Mutation Res., 257, pp. 147-204. (8) Clive, D., McCuen, R., Spector, J. F. S., Piper, C. and Mavournin, K. H. (1983), Specific Gene Mutations in L5178Y Cells in Culture. A Report of the U. S. Environmental Protection Agency Gene-Tox Program, Mutation Res., 115, pp. 225-251. (9) Li, A. P., Gupta, R. S., Heflich, R. H. and Wasson, J. S. (1988), A Review and Analysis of the Chinese Hamster Ovary/Hypoxanthine Guanine Phosphoribosyl Transferase

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Res., 115, pp. 225-251. (9) Li, A. P., Gupta, R. S., Heflich, R. H. and Wasson, J. S. (1988), A Review and Analysis of the Chinese Hamster Ovary/Hypoxanthine Guanine Phosphoribosyl Transferase System to Determine the Mutagenicity of Chemical Agents: A Report of Phase III of the U. S. Environment Protection Agency Gene-Tox Program, Mutation Res., 196, pp. 17-36. (10) Li, A. P., Carver, J. H., Choy, W. N., Hsie, A. W., Gupta, R. S., Loveday, K. S., O'Neill, J. P., Riddle, J.

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Genetics, 3, pp. 289-294. (4) Richold, M., Ashby, J., Chandley, A., Gatehouse, D. G. and Henderson L. (1990), In Vivo Cytogenetic Assays, in: D. J. Kirkland (ed.), Basic Mutagenicity Tests, UKEMS Recommended Procedures. UKEMS Subcommittee on Guidelines for Mutagenicity Testing. Report. Part I revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 115-141. (5) Yamamoto, K. and Kikuchi, Y. (1978), A New Method for Preparation of Mammalian Spermatogonial Chromosomes, Mutation Res., 52, pp. 207-209. (6) Adler, I. D., Shelby, M.

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
for Preparation of Mammalian Spermatogonial Chromosomes, Mutation Res., 52, pp. 207-209. (6) Adler, I. D., Shelby, M. D., Bootman, J., Favor, J., Generoso, W., Pacchierotti, F., Shibuya, T. and Tanaka, N. (1994), International Workshop on Standardisation of Genotoxicity Test Procedures. Summary Report of the Working Group on Mammalian Germ Cell Tests, Mutation Res., 312, pp. 313-318. (7) Fielder, R. J., Allen, J. A., Boobis, A. R., Botham, P. A., Doe, J., Esdaile, D. J., Gatehouse, D. G., Hodson-Walker, G., Morton, D. B., Kirkland D.

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Mammalian Germ Cell Tests, Mutation Res., 312, pp. 313-318. (7) Fielder, R. J., Allen, J. A., Boobis, A. R., Botham, P. A., Doe, J., Esdaile, D. J., Gatehouse, D. G., Hodson-Walker, G., Morton, D. B., Kirkland D. J. and Richold, M. (1992), Report of British Toxicology Society/UK Environmental Mutagen Society Working group: Dose setting in In Vivo Mutagenicity Assays, Mutagenesis, 7, pp. 313-319. (8) Lovell, D. P., Anderson, D., Albanese, R., Amphlett, G. E., Clare, G., Ferguson, R., Richold, M., Papworth, D.

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Clare, G., Ferguson, R., Richold, M., Papworth, D. G. and Savage, J. R. K. (1989), Statistical Analysis of In Vivo Cytogenetic Assays, in: D. J. Kirkland (ed.), Statistical Evaluation of Mutagenicity Test Data. UKEMS Sub-Committee on Guidelines for Mutagenicity Testing, report, Part III, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 184-232. ANEXA 4G " B.39. TEST IN VIVO DE SINTEZĂ NEPROGRAMATĂ A ADN (UDS) PE CELULE HEPATICE DE MAMIFERE 1. METODA Prezenta metodă este reprodusă după linia directoare

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
B., Benford, D. J., Dean, S. W. and Mitchell I. de G. (1993), In Vivo Rat Liver UDS Assay, in: Kirkland D. J. and Fox M., (eds.), Supplementary Mutagenicity Tests: UKEM Recommended Procedures. UKEMS Subcommittee on Guidelines for Mutagenicity Testing Report. Part II revised, Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, pp. 52-77. (4) Madle, S., Dean, S. W., Andrae, U., Brambilla, G., Burlinson, B., Doolittle, D. J., Furihata, C., Hertner, T., McQueen, C. A. and Mori, H. (1993

jrc4583as2000 by Guvernul României (2000) [Corola-website/Law/89749_a_90536]
Corola-website/Law/90003_a_90790

cantitățile oferite spre vânzare pe parcursul unei luni date, cresc cu 5 procente față de procentajul mediu al retragerilor de pe parcursul celor trei luni anterioare, sau b) piața se confruntă cu orice altă dificultate gravă. Produsele retrase în vederea acordării unui ajutor pentru report conform art. 23 și 24 alin. (4) din Regulamentul (CE) nr. 104/2000 nu sunt luate în calcul ca retrageri în sensul prezentului paragraf. 2. Organizația de producători informează autoritățile competente ale statului membru asupra oricărei măsuri adoptate conform alin

jrc4836as2000 by Guvernul României (2000) [Corola-website/Law/90003_a_90790]