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al., 1994629; Kang et al., 2003630; Kloner, 1988631; Zweier, 1988632). Dar acidul cafeic fenetil ester 621 Bolli R, Jeroudi MO, Patel BS, Aruoma OI, Halliwell B, Lai EK, et al. Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial ‘‘stunning’’ is a manifestation of reperfusion injury. Circ Res 1989;65(3):607- 22. 622 Liu YH, Yang XP, Sharov VG, Sigmon DH, Sabbath HN, Carretero OA. Paracrine system in
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transgenic mice. Am. J. Pathol. 163, 1579-1586. 631 Kloner RA. Introduction to the role of oxygen radicals in myocardial ischemia and infarction. Free Radic Biol Med 1988;4:5-7. MICROGRAFII ASUPRA PRODUSELOR APICOLE 204 (CAPE), component al propolisului, un flavonoid antioxidant, liposolubil, este cunoscut pentru capaciatea de a preveni formarea de ROS, malondialdehidei (MDA), precum și peroxinitrilului 633 (Ilhan et al., 1999634; Russo et al., 2002635; Song et al., 2002636; Hepsen et al., 1993637; Sud’ina et al., 1993638; Ozer et al
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Ozen, S., Uz, E., Ciralik, H., Akyol, O., 1999. The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits. Eur. J. Cardio thorac. Surg. 16, 458-463. 635 Russo, A., Longo, R., Vanella, A., 2002. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 73, S21-S29. 636 Song,Y.S., Park, E.H.,Hur, G.M., Ryu,Y.S., Lee, Y.S., Lee, J.Y., Kim,Y.M., Jin, C., 2002. Caffeic acid phenethyl
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extract of propolis to suppress corneal neurovascularisation in rabbits. Ophthalmic Res 1999;31:426. 638 Sud’ina, G.F., Mirzoeva, O.K., Pushkareva, M.A.,Korshunova, G.A., Sumbatyan, N.V., Varfolomeev, S.D., 1993. Caffeic acid ester as a lipoxygenase inhibitor with antioxidant properties. FEBS 329, 21-24. 639 Ozer, M.K., Parlakpinar, H., Acet, A., 2004. Reduction of ischemia-reperfusion induced myocardial infarct size in rats by caffeic acid phenethyl ester (CAPE). Clin. Biochem. 37, 702-705. 640 Obata T, Yamanaka Y. Protective effect of diltiazem
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al., 1995; Park, 1999; Park și Lucchesi, 1999651; Mirzoeva et al., 1995652; Melino et 643 Sud’ina, G.F., Mirzoeva, O.K., Pushkareva, M.A.,Korshunova, G.A., Sumbatyan, N.V., Varfolomeev, S.D., 1993. Caffeic acid ester as a lipoxygenase inhibitor with antioxidant properties. FEBS 329, 21-24. 644 Ozyurt, H., Irmak, M.K., Akyol, O., Sogut, S., 2001. Caffeic acid phenethyl ester changes the incides of oxidative stress in serum of rats with renal ischemia-reperfusion injury. Cell Biochem. Funct. 19, 259-263. 645 Shiang-Suo Huang
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Liu, Su-Man Lin, Pei-Hu Liao, Ruey-Hseng Lin, YuChia Chen, Chun-Lien Chih, Shen-Kou Tsai, Antiarrhythmic effect of caffeic acid phenetil ester (CAPE) on myocardial ischemia/reperfusion injury in rats, Clinical Biochemistry, 38, 2005,943-947. 646 Russo A, Longo R, Vanella A. Antioxidant activity or propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002;73: 21-9. 647 Ahmet Gurel, Ferah Armutcu, Semsettin Sahin, Sadik Sogut, Huseyin Ozyurt, Mukaddes Gulec, N. Onur Kutlu, Omer Akyol, Protective role of α tocopherol and caffeic
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myeloperoxidase in rat kidneys, Clinica Chimica 339, 2004, 33-41. 648 Muhammed Enes Altuğ, Yurdal Serarslan, Ramazan Bal, Tünay Kontaș, Fatih Ekici, Ismet M. Melek, Hüseyin Aslan, Tașkın Duman, Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: A biochemical and planimetric study, Brain Research 1 2 0 1 (2 0 0 8) 1 3 5 - 1 4 2. 649 Uzar, E., Koyuncuoglu, H.R., Uz, E., Yilmaz, H.R., Kutluhan, S., Kilbas, S., G¨ultekin, F. Caffeic acid
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phenethyl ester (CAPE) may prevent methotrexate induced cerebellar oxidative stress in rats. Toxicol. Ind. Health (in press). 650 Mirzoeva OK, Sud’ina GF, Pushkareva MA, Korshunova GA, Sumbatian NV, Varfolomeev SD. Lipophilic derivatives of caffeic acid as lipoxygenase inhibitors with antioxidant properties. Bioorg Khim 1995;21(2):143-51. 651 Park, J.L., Lucchesi, B.R., 1999. Mechanisms of myocardial reperfusion injury. Ann. Thorac. 68, 1905- 1912. 652 Mirzoeva, O.K., Sud’ina, G.F., Pushkareva,M.A.,Korshunova, G.A., Sumbatian, N.V., Varfolomeev, S.D.
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Lucchesi, B.R., 1999. Mechanisms of myocardial reperfusion injury. Ann. Thorac. 68, 1905- 1912. 652 Mirzoeva, O.K., Sud’ina, G.F., Pushkareva,M.A.,Korshunova, G.A., Sumbatian, N.V., Varfolomeev, S.D., 1995. Lipophilic derivatives of caffeic acid as lipoxygenase inhibitors with antioxidant properties. Bioorg. Chim. 21, 143-151. MICROGRAFII ASUPRA PRODUSELOR APICOLE 206 al., 2000653; Dispersin si Borgers, 2001654; Laranjinha et al., 1995655) și previne inactivarea oxidului nitric (NO) și altor radicali (Aladag et al., 2006656). Producția ROS și calciul miocardic (Ca2+), au
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2005667) Nelson et al., 1995668; Perez et al., 1999669; Najibi si Cohen, 1995670; Miura et al., 1999671; Amodio et al., 2003672; Irmark et al., 2003673; Wei et al., 2004674 ; Tsai et al., 2006675). rabbit brains against permanent focal ischemia by antioxidant action: A biochemical and planimetric study, Brain Research 1 2 0 1 ( 2 0 0 8 ) 1 3 5 - 1 4 2. 664 Nelson, M.T., Quayle, J.M., 1995. Physiological roles and properties of potassium channels in arterial smooth muscle. Am
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C.Y., Lin, S.M., Liu, S.M., Lin, R.H., Chih, C.L., Huang, S.S., 2006. Caffeic acid phenethyl ester ameliorates cerebral infarction in rats subjected to focal cerebral ischemia. Life Sci. 78, 2758-2762 MICROGRAFII ASUPRA PRODUSELOR APICOLE 208 Alți compuși cu efecte antioxidante ai propolisului sunt : β-eudesmolul, prezent în propolisul de plop (Sallah et al., 2006676), acidul 3,4 dimetoxicinamic, un puternic inhibitor al xantin-oxidazei (Chan et al., 1995677), d limonen care induce activarea GSH-Px (Van Lieshout et al., 1998678), flavonoidele și compușii
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methanolic extract of Teucrium sauvagei Le Houerou, Nat. Prod. Res. 20 (2006) 1089-1097. 677 K. Salah, M.A. Mahjoub, J.P. Chaumont, L. Michel, J. Millet-Clerc, I. Chraeif, S. Ammar, Z. Mighri, M. Aouni, Chemical composition and in vitro antifungal and antioxidant activity of the essential oil and methanolic extract of Teucrium sauvagei Le Houerou, Nat. Prod. Res. 20 (2006) 1089-1097. 678 E.M. Van Lieshout, M.P. Ekkel, M.M. Bedaf, W.A. NijhoV, W.H. Peters, EVects of dietary anticarcinogens on rat gastrointestinal
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