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Corola-website/Law/292696_a_294025

25 200 2000 UE Pesticide solide 5 500 ONU lichide 5 50 500 ONU solide 5 50 200 Elveția 5 50 500 2000 5000 SUA EPA crk 25 Japonia PDSCA 30 300 Canada/WHMIS/SUA OSHA 50 500 SUA EPA pesticide 50 500 5000 SUA CPSC 50 5000 Canada pesticide 50 500 1000 2000 - în fiecare etapă se utilizează trei animale de acelasi sex (în mod normal, femele) - ∞: neclasificat - 0,1,2,3: Numărul de animale muribunde sau moarte în fiecare

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
lichide 5 50 500 ONU solide 5 50 200 Elveția 5 50 500 2000 5000 SUA EPA crk 25 Japonia PDSCA 30 300 Canada/WHMIS/SUA OSHA 50 500 SUA EPA pesticide 50 500 5000 SUA CPSC 50 5000 Canada pesticide 50 500 1000 2000 - în fiecare etapă se utilizează trei animale de acelasi sex (în mod normal, femele) - ∞: neclasificat - 0,1,2,3: Numărul de animale muribunde sau moarte în fiecare etapă - *: în prima etapă - SGA: Sistemul global armonizat de

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
50 mg/kg) altul 3* (300 mg/kg) altul 3* (2000 mg/kg) 2* (2000 mg/kg) altul 1 0 Limită LD50 mg/kg g.c. 5 25 30 50 200 300 500 1000 2000 2500 5000 UE/Substanțe chimice pesticide lichide 25 200 2000 UE Pesticide solide 5 500 ONU lichide 5 50 500 ONU solide 5 50 200 Elveția 5 50 500 2000 5000 SUA EPA crk 25 Japonia PDSCA 30 300 Canada/WHMIS/SUA OSHA 50 500 SUA

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
mg/kg) altul 3* (2000 mg/kg) 2* (2000 mg/kg) altul 1 0 Limită LD50 mg/kg g.c. 5 25 30 50 200 300 500 1000 2000 2500 5000 UE/Substanțe chimice pesticide lichide 25 200 2000 UE Pesticide solide 5 500 ONU lichide 5 50 500 ONU solide 5 50 200 Elveția 5 50 500 2000 5000 SUA EPA crk 25 Japonia PDSCA 30 300 Canada/WHMIS/SUA OSHA 50 500 SUA EPA pesticide 50 500 5000 SUA

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
25 200 2000 UE Pesticide solide 5 500 ONU lichide 5 50 500 ONU solide 5 50 200 Elveția 5 50 500 2000 5000 SUA EPA crk 25 Japonia PDSCA 30 300 Canada/WHMIS/SUA OSHA 50 500 SUA EPA pesticide 50 500 5000 SUA CPSC 50 5000 Canada pesticide 50 500 1000 2000 - în fiecare etapă se utilizează trei animale de acelasi sex (în mod normal, femele) - ∞: neclasificat - 0,1,2,3: Numărul de animale muribunde sau moarte în fiecare

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
lichide 5 50 500 ONU solide 5 50 200 Elveția 5 50 500 2000 5000 SUA EPA crk 25 Japonia PDSCA 30 300 Canada/WHMIS/SUA OSHA 50 500 SUA EPA pesticide 50 500 5000 SUA CPSC 50 5000 Canada pesticide 50 500 1000 2000 - în fiecare etapă se utilizează trei animale de acelasi sex (în mod normal, femele) - ∞: neclasificat - 0,1,2,3: Numărul de animale muribunde sau moarte în fiecare etapă - *: în prima etapă - SGA: Sistemul global armonizat de

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Warkany J. (eds). University of Chicago, Chicago, ÎL, pp 251-277. (23) Wilson, J.G. and Fraser, F.C. (eds). (1977) Handbook of Teratology, Vol. 4. Plenum, NY. (24) Varnagy, L. (1980) Use of Recent Fetal Bone Staining Techniques în the Evaluation of Pesticide Teratogenicity. Acta Vet. Acad. Sci. Hung. 28; 233-239. (25) Staples, R.E. (1974) Detection of visceral Alterations în Mammalian Foetuses. Teratology 9; 37-38. (26) Van Julsingha, E.B. and C.G. Bennett (1977) A Dissecting Procedure for the Detection of Anomalies în the

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Italy, 18-20 January 1995 (6) ISO 10381-6 (1993). Soil quality - Sampling. Guidance on the collection, handling and storage of soil for the assessment of aerobic microbial processes în the laboratory. (7) Anderson, J.P.E. (1987). Handling and Storage of Soils for Pesticide Experiments, în "Pesticide Effects on Soil Microflora". Eds. L. Somerville and M.P. Greaves, Chap. 3:45-60. (8) Anderson, J.P.E. (1982). Soil Respiration, în "Methods of Soil Analysis - Part 2: Chemical and Microbiological Properties". Agronomy Monograph Ns 9. Eds. A.L.

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1995 (6) ISO 10381-6 (1993). Soil quality - Sampling. Guidance on the collection, handling and storage of soil for the assessment of aerobic microbial processes în the laboratory. (7) Anderson, J.P.E. (1987). Handling and Storage of Soils for Pesticide Experiments, în "Pesticide Effects on Soil Microflora". Eds. L. Somerville and M.P. Greaves, Chap. 3:45-60. (8) Anderson, J.P.E. (1982). Soil Respiration, în "Methods of Soil Analysis - Part 2: Chemical and Microbiological Properties". Agronomy Monograph Ns 9. Eds. A.L. Page, R.H. Miller

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
de transformare propuse, daca este cazul; - discutarea și interpretarea rezultatelor; - date brute (de exemplu cromatogramele probelor, calculele privind viteza de transformare a probelor și mijloacele utilizate pentru identificarea produșilor de transformare). 4. REFERINȚE BIBLIOGRAFICE: (1) UȘ- Environmental Protection Agency (1982). Pesticide Assessment Guidelines, Subdivision N. Chemistry: Environmental Fâțe. (2) Agriculture Canada (1987). Environmental Chemistry and Fâțe. Guidelines for registration of pesticides în Canada. (3) Uniunea Europeană (UE) (1995). Directivă 95/36/ CE din 14 iulie 1995 de modificare a Directivei 91/414

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
Directivei 91/414/ CEE a Consiliului privind introducerea pe piață a produselor fitofarmaceutice, anexă ÎI partea A și anexă III partea A: Evoluție și comportamentul în mediu. (4) Dutch Commission for Registration of Pesticides (1995). Application for registration of a pesticide. Section G: Behaviour of the product and its metabolites în soil, water and air. (5) BBA (1986). Richtlinie für die amtliche Prüfung von Pflanzenschutzmitteln, Teil IV, 4-1. Verbleib von Pflanzenschutzmitteln im Boden - Abbau, Umwandlung und Metabolismus. (6) ISO/DIS 11266-1

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Final Report of the OECD Workshop on Selection of Soils/Sediments, Belgirate, Italy, 18-20 January 1995. (11) Guth, J.A. (1980). The study of transformations. În Interactions between Herbicides and the Soil (R.J. Hance, Ed.), Academic Press, 123-157. (12) DFG: Pesticide Bound Residues în Soil. Wiley - VCH (1998). (13) T.R. Roberts: Non extractable pesticide residue în soils and plants. Pure Appl. Chem. 56, 945-956 (IUPAC 1984) (14) OECD Test Guideline 304 A: Inherent Biodegradability în Soil (adopted 12 May 1981) (15

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
18-20 January 1995. (11) Guth, J.A. (1980). The study of transformations. În Interactions between Herbicides and the Soil (R.J. Hance, Ed.), Academic Press, 123-157. (12) DFG: Pesticide Bound Residues în Soil. Wiley - VCH (1998). (13) T.R. Roberts: Non extractable pesticide residue în soils and plants. Pure Appl. Chem. 56, 945-956 (IUPAC 1984) (14) OECD Test Guideline 304 A: Inherent Biodegradability în Soil (adopted 12 May 1981) (15) ISO 10381-6 (1993). Soil quality - Sampling - Part 6. Guidance on the collection, handling

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
and storage of soil for the assessment of aerobic microbial processes în the laboratory. (16) Anexă V la Directivă 67/548/CEE. (17) Guth, J.A. (1981). Experimental approaches to studying the fâțe of pesticides în soil. În Progress în Pesticide Biochemistry. D.H. Hutson, T.R. Roberts, Eds. J. Wiley & Sons, Vol. 1, 85-114. (18) Soil texture Classification (UȘ and FAO systems): Weed Science, 33, Suppl. 1 (1985) and Soil Sci. Șoc. Amer. Proc. 26:305 (1962). (19) Methods of Soil

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
soils. Soil Biol. Biochem. 10,215 221. (25) ISO 14240-1 and 2 (1997). Soil Quality - Determination of soil microbial biomass - Part 1: Substrate-induced respiration method. Part 2: fumigation extraction method. (26) Anderson, J.P.E. (1987). Handling and storage of soils for pesticide experiments. În Pesticide Effects on Soil Microflora. L. Somerville, M.P. Greaves, Eds. Taylor & Francis, 45-60. (27) Kato, Yasushiro. (1998). Mechanism of pesticide transformation în the environment: Aerobic and bio-transformation of pesticides în aqueous environment. Proceedings of the 16th Symposium

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
Biochem. 10,215 221. (25) ISO 14240-1 and 2 (1997). Soil Quality - Determination of soil microbial biomass - Part 1: Substrate-induced respiration method. Part 2: fumigation extraction method. (26) Anderson, J.P.E. (1987). Handling and storage of soils for pesticide experiments. În Pesticide Effects on Soil Microflora. L. Somerville, M.P. Greaves, Eds. Taylor & Francis, 45-60. (27) Kato, Yasushiro. (1998). Mechanism of pesticide transformation în the environment: Aerobic and bio-transformation of pesticides în aqueous environment. Proceedings of the 16th Symposium on Environmental Science

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
respiration method. Part 2: fumigation extraction method. (26) Anderson, J.P.E. (1987). Handling and storage of soils for pesticide experiments. În Pesticide Effects on Soil Microflora. L. Somerville, M.P. Greaves, Eds. Taylor & Francis, 45-60. (27) Kato, Yasushiro. (1998). Mechanism of pesticide transformation în the environment: Aerobic and bio-transformation of pesticides în aqueous environment. Proceedings of the 16th Symposium on Environmental Science of Pesticides, 105-120. (28) Keuken O., Anderson J.P.E. (1996). Influence of storage on biochemical processes în soil. În Pesticides, Soil

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
J.W. (1976). The application of mathematical modelling to the soil persistence and accumulation of pesticides. Proc. BCPC Symposium: Persistence of Insecticides and Herbicides, 181-199. (33) Goring C.A.I., Laskowski, D.A., Hamaker, J.W., Meikle, R.W. (1975). Principles of pesticide degradation în soil. În "Environmental Dynamics of Pesticides". R. Haque and V.H. Freed, Eds., 135-172. (34) Timme, G., Freshe, H., Laska, V. (1986). Statistical interpretation and graphic representation of the degradational behaviour of pesticide residues. ÎI. Pflanzenschutz - Nachrichten Bayer 39

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
Meikle, R.W. (1975). Principles of pesticide degradation în soil. În "Environmental Dynamics of Pesticides". R. Haque and V.H. Freed, Eds., 135-172. (34) Timme, G., Freshe, H., Laska, V. (1986). Statistical interpretation and graphic representation of the degradational behaviour of pesticide residues. ÎI. Pflanzenschutz - Nachrichten Bayer 39, 188-204. (35) Timme, G., Freshe, H. (1980). Statistical interpretation and graphic representation of the degradational behaviour of pesticide residues. I. Pflanzenschutz - Nachrichten Bayer 33, 47-60. (36) Gustafson D.I., Holden L.R. (1990). Non-linear pesticide dissipation

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
G., Freshe, H., Laska, V. (1986). Statistical interpretation and graphic representation of the degradational behaviour of pesticide residues. ÎI. Pflanzenschutz - Nachrichten Bayer 39, 188-204. (35) Timme, G., Freshe, H. (1980). Statistical interpretation and graphic representation of the degradational behaviour of pesticide residues. I. Pflanzenschutz - Nachrichten Bayer 33, 47-60. (36) Gustafson D.I., Holden L.R. (1990). Non-linear pesticide dissipation în soil; a new model based on spațial variability. Environm. Sci. Technol. 24, 1032-1041. (37) Hurle K., Walker A. (1980). Persistence and its prediction

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
of pesticide residues. ÎI. Pflanzenschutz - Nachrichten Bayer 39, 188-204. (35) Timme, G., Freshe, H. (1980). Statistical interpretation and graphic representation of the degradational behaviour of pesticide residues. I. Pflanzenschutz - Nachrichten Bayer 33, 47-60. (36) Gustafson D.I., Holden L.R. (1990). Non-linear pesticide dissipation în soil; a new model based on spațial variability. Environm. Sci. Technol. 24, 1032-1041. (37) Hurle K., Walker A. (1980). Persistence and its prediction. În Interactions between Herbicides and the Soil (R.J. Hance, Ed.), Academic Press, 83-122. ANEXĂ 1

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
1) Guth, J.A. (1980). The study of transformations. În Interactions between Herbicides and the Soil (R.J. Hance, Ed.), Academic Press, 123-157. (2) Guth, J.A. (1981). Experimental approaches to studying the fâțe of pesticides în soil. În Progress în Pesticide Biochemistry (D.H. Hutson, T.R. Roberts, Eds. J. Wiley & Sons. Vol. 1, 85-114. (3) Anderson J.P.E. (1975). Einfluss von Temperatur und Feuchte auf Verdampfung, Abbau und Festlegung von Diallat im Boden. Z. PflKrankh Pflschutz, Sonderheft VII, 141-146. C.24. TRANSFORMĂRI

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
1) BBA-Guidelines for the examination of plant protectors în the registration process. (1990). part IV, Section 1-5: Degradability and fâțe of plant protectors în the water/sediment system. Germany. (2) Commission for registration of pesticides: Application for registration of a pesticide. (1991). Part G. Behaviour of the product and its metabolites în soil, water and air, Section G.2.1 (a). The Netherlands. (3) MAFF Pesticides Safety Directorate. (1992). Preliminary guideline for the conduct of biodegradability tests on pesticides în natural

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
conduct of biodegradability tests on pesticides în natural sediment/water systems. Ref No SC 9046. United-Kingdom. (4) Agriculture Canada: Environmental chemistry and fâțe. Guidelines for registration of pesticides în Canada. Aquatic (Laboratory) - Anaerobic and aerobic. Canada. pp. 35-37. (5) US-EPA: Pesticide assessment guidelines, Subdivision N. Chemistry: Environmental fâțe (1982). Section 162-3, Anaerobic aquatic metabolism. (6) SETAC-Europe publication. (1995). Procedures for assessing the environmental fâțe and ecotoxicity of pesticides. Ed, Dr Mark R. Lynch, SETAC-Europe, Brussels. (7) OECD Test Guidelines Programme. (1995

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]
sediments, Belgirate, Italy, 18-20 January 1995. (8) ISO/DIS 5667-12. (1994). Water quality - Sampling - Part 12: Guidance on sampling of bottom sediments. (9) US-EPA (1998a). Sediment/water microcosm biodegradation test. Harmonised Test Guidelines (OPPTS 835.3180). EPA 712-C-98-080. (10) DFG: Pesticide Bound Residues în Soil. Wiley-VCH (1998). (11) T.R. Roberts: Non extractable pesticide residues în soils and plants. Pure Appl. Chem. 56, 945-956 (IUPAC 1984). (12) OECD Test Guideline 304 A: Inherent Biodegradability în Soil (adopted 12 May 1981). (13) OECD

32004L0073-ro (2004) [Corola-website/Law/292696_a_294025]