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of oxidative stress in serum of rats with renal ischemia-reperfusion injury. Cell Biochem. Funct. 19, 259-263. 645 Shiang-Suo Huang, Shen Ming Liu, Su-Man Lin, Pei-Hu Liao, Ruey-Hseng Lin, YuChia Chen, Chun-Lien Chih, Shen-Kou Tsai, Antiarrhythmic effect of caffeic acid phenetil ester (CAPE) on myocardial ischemia/reperfusion injury in rats, Clinical Biochemistry, 38, 2005,943-947. 646 Russo A, Longo R, Vanella A. Antioxidant activity or propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002;73: 21-9. 647 Ahmet Gurel, Ferah
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Chun-Lien Chih, Shen-Kou Tsai, Antiarrhythmic effect of caffeic acid phenetil ester (CAPE) on myocardial ischemia/reperfusion injury in rats, Clinical Biochemistry, 38, 2005,943-947. 646 Russo A, Longo R, Vanella A. Antioxidant activity or propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002;73: 21-9. 647 Ahmet Gurel, Ferah Armutcu, Semsettin Sahin, Sadik Sogut, Huseyin Ozyurt, Mukaddes Gulec, N. Onur Kutlu, Omer Akyol, Protective role of α tocopherol and caffeic acid phenethyl ester on ischemia-reperfusion injuri via nitric oxide
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propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002;73: 21-9. 647 Ahmet Gurel, Ferah Armutcu, Semsettin Sahin, Sadik Sogut, Huseyin Ozyurt, Mukaddes Gulec, N. Onur Kutlu, Omer Akyol, Protective role of α tocopherol and caffeic acid phenethyl ester on ischemia-reperfusion injuri via nitric oxide and myeloperoxidase in rat kidneys, Clinica Chimica 339, 2004, 33-41. 648 Muhammed Enes Altuğ, Yurdal Serarslan, Ramazan Bal, Tünay Kontaș, Fatih Ekici, Ismet M. Melek, Hüseyin Aslan, Tașkın Duman, Caffeic acid phenethyl ester protects
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phenethyl ester on ischemia-reperfusion injuri via nitric oxide and myeloperoxidase in rat kidneys, Clinica Chimica 339, 2004, 33-41. 648 Muhammed Enes Altuğ, Yurdal Serarslan, Ramazan Bal, Tünay Kontaș, Fatih Ekici, Ismet M. Melek, Hüseyin Aslan, Tașkın Duman, Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: A biochemical and planimetric study, Brain Research 1 2 0 1 (2 0 0 8) 1 3 5 - 1 4 2. 649 Uzar, E., Koyuncuoglu, H.R., Uz, E., Yilmaz, H.R.
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A biochemical and planimetric study, Brain Research 1 2 0 1 (2 0 0 8) 1 3 5 - 1 4 2. 649 Uzar, E., Koyuncuoglu, H.R., Uz, E., Yilmaz, H.R., Kutluhan, S., Kilbas, S., G¨ultekin, F. Caffeic acid phenethyl ester (CAPE) may prevent methotrexate induced cerebellar oxidative stress in rats. Toxicol. Ind. Health (in press). 650 Mirzoeva OK, Sud’ina GF, Pushkareva MA, Korshunova GA, Sumbatian NV, Varfolomeev SD. Lipophilic derivatives of caffeic acid as lipoxygenase inhibitors with antioxidant properties
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effects on vitamin E content in low density lipoproteins oxidized by ferrylmyoglobin: consumption vs. regeneration. Arch. Biochem. Biophys. 323, 373-381. 656 Aladag, M.A., Turkoz, Y., Ozcan, C., Sahna, E., Parlakpınar, H., Akpolat, N., Cigremis, Y., 2006. Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels. Int. J. Devl. Neurosci. 24, 9-14. 657 Abbate, A., Biondi-Zoccai, G.G., Baldi, A., 2002. Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling. J. Cell
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2537. 659 Goldhaber, J.I., Weiss, J.N., 1992. Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension 20, 118-127. 660 Irmak, M.K., Fadillioglu, E., Sogut, S., Erdogan, H., Gulec, M., Ozer, M., Yagmurca, M., Gozukara, M.E., 2003. Effects of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brain. Cell Biochem. Funct. 21, 283-289. 661 Shen-Kou Tsai, Min-Jon Lin, Pei-Hu Liao, Chi-Yea Yang, Su-Man Lin, Sheng-Ming Liu, Ruey-Hseng Lin, Chun-Lien Chih, Shiang-Suo Huang, Caffeic acid phenethyl ester ameliorates cerebral infarction in
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of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brain. Cell Biochem. Funct. 21, 283-289. 661 Shen-Kou Tsai, Min-Jon Lin, Pei-Hu Liao, Chi-Yea Yang, Su-Man Lin, Sheng-Ming Liu, Ruey-Hseng Lin, Chun-Lien Chih, Shiang-Suo Huang, Caffeic acid phenethyl ester ameliorates cerebral infarction in rats subjected to focal cerebral ischemia, Life Sciences 78 (2006) 2758 - 2762 662 Khan, M., Elango, C., Ansari, M.A., Singh, I., Singh, A.K., 2007. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat
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Chih, Shiang-Suo Huang, Caffeic acid phenethyl ester ameliorates cerebral infarction in rats subjected to focal cerebral ischemia, Life Sciences 78 (2006) 2758 - 2762 662 Khan, M., Elango, C., Ansari, M.A., Singh, I., Singh, A.K., 2007. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J. Neurochem. 102, 365-377. 663 Muhammed Enes Altuğ, Yurdal Serarslan, Ramazan Bal, Tünay Kontaș, Fatih Ekici, Ismet M. Melek, Hüseyin Aslan, Tașkın Duman, Caffeic acid phenethyl ester protects
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phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J. Neurochem. 102, 365-377. 663 Muhammed Enes Altuğ, Yurdal Serarslan, Ramazan Bal, Tünay Kontaș, Fatih Ekici, Ismet M. Melek, Hüseyin Aslan, Tașkın Duman, Caffeic acid phenethyl ester protects MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 207 conducând la scăderea potasiului (Nelson si Quayle, 1995664; Cogolludo et al., 2007665; Lin et al., 2004666; Shieh et al., 2005667) Nelson et al., 1995668; Perez et al., 1999669; Najibi si Cohen
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2007. The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation. Cardiovasc. Res. 73, 424- 431. 666 Lin, M.W., Yang, S.R., Huang, M.H., Wu, S.N., 2004. Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF κB activation, on Ca2+-activated K+ current in pituitary GH3 cells. J. Biol. Chem. 279, 26885- 26892. 667 Shieh, D.B., Yang, S.R., Shi, X.Y., Wu, Y.N., Wu, S.N., 2005. Properties of BKCa channels
MICROGRAFII ASUPRA PRODUSELOR APICOLE by Andriţoiu Călin Vasile [Corola-publishinghouse/Science/273_a_935]
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D.D., 1999. Human coronary arteriolar dilation to bradykinin depends on membrane hyperpolarization. Circulation 99, 3132-3138. 672 Amodio, R., Ruvo, C.D., Matteo, V.D., Poggi, A., Santo, A.D., Martelli, N., Lorenzet, R., Rotilio, D., Cacchio, M., Esposito, E., 2003. Caffeic acid phenethyl ester blocks apoptosis induced by low potassium in cerebellar granule cells. Int. J. Devl. Neurosci. 21, 379-389. 673 Irmak, M.K., Fadillioglu, E., Sogut, S., Erdogan, H., Gulec, M., Ozer, M., Yagmurca, M., Gozukara, M.E., 2003. Effects of caffeic acid phenethyl ester
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ester blocks apoptosis induced by low potassium in cerebellar granule cells. Int. J. Devl. Neurosci. 21, 379-389. 673 Irmak, M.K., Fadillioglu, E., Sogut, S., Erdogan, H., Gulec, M., Ozer, M., Yagmurca, M., Gozukara, M.E., 2003. Effects of caffeic acid phenethyl ester and alpha tocopherol on reperfusion injury in rat brain. Cell Biochem. Funct. 21, 283-289. 674 Wei, X., Zhao, L., Ma, Z., Holtzman, D.M., Yan, C., Dodel, R.C., Hampel, H., Oertel, W., Farlow, M.R., Du, Y., 2004. Caffeic acid phenethyl ester
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ester and alpha tocopherol on reperfusion injury in rat brain. Cell Biochem. Funct. 21, 283-289. 674 Wei, X., Zhao, L., Ma, Z., Holtzman, D.M., Yan, C., Dodel, R.C., Hampel, H., Oertel, W., Farlow, M.R., Du, Y., 2004. Caffeic acid phenethyl ester prevents neonatal hypoxic- ischaemic brain injury. Brain 127, 2629-2635. 675 Tsai, S.K., Lin, M.J., Liao, P.H., Yang, C.Y., Lin, S.M., Liu, S.M., Lin, R.H., Chih, C.L., Huang, S.S., 2006. Caffeic acid phenethyl ester ameliorates cerebral infarction in rats subjected
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Du, Y., 2004. Caffeic acid phenethyl ester prevents neonatal hypoxic- ischaemic brain injury. Brain 127, 2629-2635. 675 Tsai, S.K., Lin, M.J., Liao, P.H., Yang, C.Y., Lin, S.M., Liu, S.M., Lin, R.H., Chih, C.L., Huang, S.S., 2006. Caffeic acid phenethyl ester ameliorates cerebral infarction in rats subjected to focal cerebral ischemia. Life Sci. 78, 2758-2762 MICROGRAFII ASUPRA PRODUSELOR APICOLE 208 Alți compuși cu efecte antioxidante ai propolisului sunt : β-eudesmolul, prezent în propolisul de plop (Sallah et al., 2006676), acidul 3,4
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arrhythmias after acute coronary artery ligation in anesthetized rats. J Pharmacol Exp Ther 1982;223:580- 6. 693 Shiang-Suo Huang, Shen-Ming Liu, Su-Man Lin, Pei-Hu Liao, Ruey-Hseng Lin, YuChia Chen, Chun-Lien Chih, Shen-Kou Tsai, Antiarrhythmic effect of caffeic acid phenetil ester (CAPE) on myocardial ischemia/reperfusion injury in rats, Clinical Biochemistry, 38, 2005,943-947. 694 Walker MJ, Curtis MJ, Hearse DJ, Campbell RW, Janse MJ, Yellon DM, et al. The Lambeth Conventions: guidelines for the study of arrhythmias in ischemia infarction
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Amodino et al., 2003). Efectul vasorelaxant al propolisului CAPE manifestă efect vasodilatator (Cicala et al., 2003; Yuan Long et al., 2009702), asupra endoteliului și efect inhibitor asupra circulației Ca2+ (Cicala et al., 2003703; Yuan Long et al., 2009), prin membrana ester (CAPE) on myocardial ischemia/reperfusion injury in rats, Clinical Biochemistry, 38, 2005,943-947. 696 Holly, T.A., Drincic, A., Byun, Y., Nakamura, S., Harris, K., Klocke, F.J., Cryns, V.L., 1999. Caspase inhibition reduces myocyte cell death induced by myocardial ischemia
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K., Lorenz-Meyer, S., Bode, C., Schaper, J., 2001. The role of apoptosis in myocardial ischemia: a critical appraisal. Basic. Res. Cardiol. 96, 219-226. 701 Parlakpinar H, E. Sahna, A. Acet, B. Mizrak, A. Polat, Protective effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia- reperfusion-induced apoptotic cell death, Toxicology 209 (2005) 1-14 702 Yuan Long, Min Han, Juan Chen, Xiao-Zhu Tian, Qiang Chen, Rui Wang, The vasorelaxant effect of caffeic acid phenethyl ester on porcine coronary artery ring segments, Vascular
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Polat, Protective effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia- reperfusion-induced apoptotic cell death, Toxicology 209 (2005) 1-14 702 Yuan Long, Min Han, Juan Chen, Xiao-Zhu Tian, Qiang Chen, Rui Wang, The vasorelaxant effect of caffeic acid phenethyl ester on porcine coronary artery ring segments, Vascular Pharmacology 51 (2009) 78- 83. 703 Cicala, C., Morello, S., Iorio, C., Capasso, R., Borrelli, F., Mascolo, N., 2003. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life
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The vasorelaxant effect of caffeic acid phenethyl ester on porcine coronary artery ring segments, Vascular Pharmacology 51 (2009) 78- 83. 703 Cicala, C., Morello, S., Iorio, C., Capasso, R., Borrelli, F., Mascolo, N., 2003. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sci. 73, 73-80. MICROGRAFII ASUPRA PRODUSELOR APICOLE Andrițoiu Călin Vasile 211 celulelor și a celulelor musculare vasculare netede (Cicala et al., 2003704), inhibă activitatea catalitică indusă de sinteza oxidului nitric (iNOS) și expresia
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Molenar et al., 1988; Ahlguist, 1948711; Kobilka,1991712; Gerd, 2002713; Kuriama et al., 1982), și a AMP ar putea fi 704 Cicala, C., Morello, S., Iorio, C., Capasso, R., Borrelli, F., Mascolo, N., 2003. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sciences 73 (1), 73- 80. 705 Song, Y.S., Park, E.H., Hur, G.M., Ryu, Y.S., Lee, Y.S., Lee, J.Y., Kim, Y.M., Jin, C., 2002. Caffeic acid phenethyl ester inhibits
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phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sciences 73 (1), 73- 80. 705 Song, Y.S., Park, E.H., Hur, G.M., Ryu, Y.S., Lee, Y.S., Lee, J.Y., Kim, Y.M., Jin, C., 2002. Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett. 175, 53-61. 706 Koltuksuz U, Ozen S, Uz E, Aydinc M, Karaman A, Gultek A, et al. Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats. J Pediatr
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Y.M., Jin, C., 2002. Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett. 175, 53-61. 706 Koltuksuz U, Ozen S, Uz E, Aydinc M, Karaman A, Gultek A, et al. Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats. J Pediatr Surg 1999;34:1458- 62. 707 Koltuksuz U, Irmak MK, Karaman A, Uz E, Var A, O¨ zyurt H, et al. Testicular nitric oxide levels after unilateral testicular torsion/detorsion in rats
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rats. J Pediatr Surg 1999;34:1458- 62. 707 Koltuksuz U, Irmak MK, Karaman A, Uz E, Var A, O¨ zyurt H, et al. Testicular nitric oxide levels after unilateral testicular torsion/detorsion in rats pretreated with caffeic acid phenethyl ester. Urol Res 2000;28:360-3. 708 Park KH, Rubin LE, Gross SS, Levi R. Nitric oxide is a mediator of hypoxic coronary vasodilatation. Relation to adenosine and cyclooxygenasederived metabolites. Circ Res 1992;71:992- 1001. 709 Nakanishi K, Vinten-Johansen J
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F., 2007. The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation. Cardiovasc. Res. 73, 424-431. 719 Lin, M.W., Yang, S.R., Huang, M.H., Wu, S.N., 2004. Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF κB activation, on Ca2+-activated K+ current in pituitary GH3 cells. J. Biol. Chem. 279, 26885- 26892. 720 Shieh, D.B., Yang, S.R., Shi, X.Y., Wu, Y.N., Wu, S.N., 2005. Properties of BKCa channels
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