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studiază 9 cazuri), dar și sângele acestora este dulce. El constată (ca și Paracelsus, 1493-1541) că după evaporare urinei rămâne o substanță uscată, care are mirosul și gustul zahărului brun (în lucrarea „Experiments and observation on the urine in diabetes”, Med. Obs. Ing. 5: 298-316, 1776). El consideră că zahărul din urină provine din cel existent în sânge, sugerând pentru prima dată creșterea glucozei și în sânge (48). În 1797 (două decenii mai târziu), John Rollo, chirurg din Edinburgh (născut în
Tratat de diabet Paulescu by Constantin Ionescu-Tîrgovişte () [Corola-publishinghouse/Science/92244_a_92739]
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nici în alte organe. Pentru acest motiv, a preferat să spună că diabetul zaharat este o boală cu sediu necunoscut („morbus in sede incerta locus”). De o atenție sporită s-a bucurat ficatul, ca organ posibil cauzator al diabetului. Richard Med (1673-1754) a susținut teoria hepatică a diabetului, întrucât ficatul multor pacienți diabetici era mărit în volum. Stabilirea de către Claude Bernard a rolului ficatului în reglarea glicemică, prin intervenția „funcției glicogenice” a acestui organ, a readus în discuție originea hepatică a
Tratat de diabet Paulescu by Constantin Ionescu-Tîrgovişte () [Corola-publishinghouse/Science/92244_a_92739]